Companies and organisations continue to report clinical trial disruptions, which includes delayed initiation, enrollment suspension and slow enrollment due to the Covid-19 pandemic. The total number of clinical trials disrupted showed slow enrollment was the top reason, followed by enrollment suspension and lastly delayed initiation (Figure 1).

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials
When analysing these disrupted trials by therapy area, oncology leads all others in disrupted clinical trials due to the Covid-19 pandemic. Phase II has the most oncology disrupted clinical trials, followed by Phase I and then Phase III. A further breakdown can be seen in Figure 2. Furthermore, when looking at the region, North America outnumbered all other regions in disrupted clinical trials in both multinational and single-country trials. Europe was second in both, followed by Asia-Pacific, the Middle East and Africa and South and Central America (Figure 3). North America far exceeds all other regions when it comes to single-country disrupted clinical trials.
