Biovays Biotechnology CRO and Biomarker Solutions Provider

A biotechnology CRO and biomarker solutions provider, Biovays offers you specialist knowledge, innovative approaches and cost-effective alternatives for your research projects. From target discovery through to FDA approval, biomarker analysis streamlines drug development, reduces costs and boosts drug approval success rates.

Protein biomarker services

Biovays boasts unique knowledge in the expression, localisation and quantification of protein biomarkers. As increasingly specific and reliable indicators of disease states and drug efficacy, biomarkers are offering the industry new cost-cutting, time-saving solutions for improved drug success.

The experience and expertise of our research team, coupled with the flexibility and reactivity of our organisation, enables us to intervene at any stage of discovery and development programmes.

During the early stages our biomarker services enable more discriminating tests of function and toxicity, facilitating candidate selection and enriching proof-of-concept studies in order to pre-empt failures and focus research on the most promising therapeutic solutions. In the development phase we help validate potential candidates and identify viable targets. During the latter stages we help prove product safety and effectiveness, guide trial design and support critical decision-making.

We offer improved pipeline quality, decreased cycle times and improved cost-effectiveness, which leads to better, faster and cheaper biomarker services for our clients. Our services include:

• Target discovery and validation
• Predictive toxicology and dose selection
• Drug candidate selection and validation
• Drug efficacy testing
• Biomarker assay development
• Patient stratification and monitoring

Biomarker analysis and contract research services

Drawing upon a wealth of experience and a knowledge base spanning various interrelated and specialist fields of research, Biovays proposes a wide range of functional models with diverse applications for research projects. Each service offering is fully customised and models are optimised for the study of the candidate under investigation.

A unique combination of conventional and cutting-edge techniques sets our models apart – both in terms of efficacy and versatility – and thanks to a technical platform offering the very latest in biological imaging and analysis technology*, we are able to perform highly accurate, real-time quantification of biological targets to deliver our clients relevant, high-quality data on budget and on time.

Tools and techniques we use include:

• Laser confocal HD miscroscopy*
• Cellular and tissular imaging
• Videomicroscopy*
• Cell culture and molecular biology
• Fluorescence-based IHC
• Surface protein expression
• Image acquisition systems*
• Flow cytometry
• Automated image analysis (BIP)
• ELISA
• Histology
• TIRF imaging (protein-protein interactions)*

Biological imaging and image analysis

The Biovays ImagePro (BIP) biological imaging and image analysis tool is a proprietary, stand-alone software for protein expression, localisation and quantification.

It offers digital imaging of fluorescent labelling and automated quantitative analysis of immunolabelled target molecules, as well as measurement of protein expression in tissue sections and cells, biomarker colocalisation analysis, inter-protein interaction analysis, structure analysis (folding), and GPCR internalisation.

Pathologies and therapeutic areas of biomarker analysis

Biovays provides biomarker analysis services in the following pathologies and therapeutic areas:

• Cancer (solid tumours and mucositis)
• Inflammatory diseases (Crohn’s, ulcerative colitis, psoriasis, etc.)
• Metabolic diseases (diabetes, atherosclerosis, etc.)
• Respiratory diseases (asthma, COPD, fibrosis, etc.)

Biovay’s biomarker services cover the following organs and tissues (among others):

• Gastrointestinal tract
• Cardiovascular system
• Lungs
• Skin

Biomarker service models and applications

The models and applications of Biovay’s biomarker services are:

• In vitro and ex vivo models
• Human and animal tissues and cell cultures
• Wound-healing assay
• Endothelial inflammation model
• Internalisation of receptors
• Human primary mononuclear cell model
• Paneth cell model
• Signalling, cellular trafficking and drug delivery pathways
• Apoptosis and cell adhesion assays
• Morphometric analysis

Personalised biomarker services

We offer fully customised protocols and personalised services, as well as absolute client confidentiality, timely project delivery, a consulting service and technical support. We use state-of-the-art technology and techniques in our cutting-edge research and innovative solutions. Quality control and quality research is assured, as is exclusivity; each unique project has a unique team.

*Olympus HD microscopy and image analysis