Solid Form Solutions Ltd
Roslin Biocentre
Wallace Building
Scotland
Roslin, Midlothian
EH25 9PP
Other
United Kingdom
Salt, Polymorph and Co-Crystallisation Screening, Crystallisation Development, and Synthetic Chemistry
Roslin Biocentre,
Wallace Building,
Scotland,
Roslin, Midlothian,
EH25 9PP Other,
United Kingdom
Solid Form Solutions is a world-leading contract research organisation (CRO) providing the pharmaceutical industry with chemical development services. Our work programmes include:
Our services can either be used separately to solve specific problems, or in parallel to deliver a larger drug development programme that will seamlessly bring the best synthetic chemistry route to the most developable solid form of a drug molecule.
Our aim is to be flexible, understand our clients’ requirements and deliver workable solutions. Whether our expertise is required to locate a synthetic route or tackle specific problems encountered during drug manufacture, Solid Form Solutions will provide an unrivalled service.
Solid Form Solutions provides a salt screening and selection programme that aims to deliver a number of developable salt forms. Our services are focused on screening a range of counterions based on:
Solid Form Solutions provides polymorph screening services that focus on delivering the most developable crystalline form, coupled with a thorough understanding of the polymorphic space surrounding an API. Furthermore, our extensive polymorph screening programme and thorough examination of data ensures better protection of our customers’ intellectual property (IP).
Our unique approach to polymorphism allows us to carry out a very large number of experiments on a very small amount of drug material.
Our study read-out time can be very short (two weeks) without any compromise on data quality, or process space investigated.
The scope of our polymorph screening programme and salt selection studies can be tailored to meet the requirements of our customers.
Solid Form Solutions’ approach to co-crystals is based on over ten years’ experience in the co-crystal sector, coupled with detailed in-house research. The design of our screens incorporates a wide range of methods that include, among others:
As well as aiming to modify the physicochemical, co-crystal screening at Solid Form Solutions is extensive enough to provide our customers with the further IP protection of their APIs.
Often when an API enters into development the solid form is not crystalline. Solid Form Solutions offers an extensive crystallisation service focusing on obtaining a crystalline and easily isolated form of the drug.
Combined with our knowledge of downstream processing Solid Form Solutions will deliver a scalable solution.
Solid Form Solutions’ batch process development service is aimed at developing a bench-scale process into a robust procedure that can easily be transferred to a plant. Solid Form Solutions aims to deliver a controlled process that yields batches of API that exhibit consistent physical properties.
Our experienced synthetic chemistry team is capable of locating the first route to a drug molecule and delivering a scaled-up, optimised process. Our capabilities include:
Our specialised equipment capability includes:
Whether our synthetic work programmes are used separately, or in tandem with a screening activity, Solid Forms Solutions will deliver the most efficient synthetic chemistry.
Solid Form Solutions works to the highest possible quality standards, and has a dedicated team to ensure these standards are met. As a part of the studies performed at Solid Form Solutions, clients can have their projects audited by the Solid Form Solutions QA section. Independent of the technical team, the QA section will report regularly to clients on the quality aspects of their project, and provide final sign off.
Roslin Biocentre
Wallace Building
Scotland
Roslin, Midlothian
EH25 9PP
Other
United Kingdom