Malvern Panalytical Biopharmaceutical and Drug Development
Malvern Panalytical offers characterisation tools for molecular analysis and small drug discovery to help accelerate development for the pharmaceutical industry.
Malvern Panalytical provides characterisation technologies to the drug development industry that advance production processes by increasing productivity and yielding high-quality products at short time-to-market.
The company’s portfolio features a range of automated analysis tools and systems that provide information on key attributes such as particle size, shape, chemical identity, molecular weight, size, and concentration.
These reliable and robust characterisation techniques help drug development companies predict how a product will perform during use and allow for optimisation.
Systems for critical material attribute information
Malvern Panalytical has a wide range of experience in small molecule pharmaceuticals.
Services include systems that provide information on variables identified as critical material attributes (CMA) such as particle size, shape and chemical identity, or molecular weight and size.
Whether characterising particle size and morphological properties of a novel active pharmaceutical ingredient (API) or rheological attributes of a new chemical entity (NCE), Malvern Panalytical can achieve efficiency using common platform technologies.
Small molecule drug discovery and development
Malvern Panalytical’s range of analytical solutions focuses on testing and manufacturing requirements, while taking into account time and cost pressures, as well as sample availability and complexity.
Label-free technologies appeal to researchers across various applications, including biological research, biotherapeutic and small molecule drug discovery and development, immunogenicity studies, vaccine development and quality control.
Label-free techniques are used in the direct study of native molecules, and generate biologically relevant data enabling understanding of molecular interactions without using artificial probes or labels.
Isothermal titration calorimetry for biomolecular interactions
Malvern Panalytical’s MicroCal range includes isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC).
ITC is used in quantitative studies of a range of biomolecular interactions, that work by directly measuring heat that is either released or absorbed during a biomolecular binding event.
By providing a complete thermodynamic profile of the molecular interaction, ITC can explain mechanisms’ underlying interactions, and enable more confident decision-making in hit selection and lead optimisation.
DSC is used to characterise stability of a protein or other biomolecules directly in its native form, and achieves this by measuring heat change associated with the molecule’s thermal denaturation.
Precise and high-quality data obtained from DSC provides vital information on protein stability in process development, and in the formulation of potential therapeutic candidates.
Size exclusion chromatography systems for assessment of product purity
Malvern Panalytical’s analytical toolbox for biopharmaceutical development is tailored to provide trusted solutions such as OMNISEC size exclusion chromatography systems to assess product purity.
The Zetasizer range is also available for sizing and zeta potential analysis for product stability.
The company’s Archimedes and NanoSight systems quantify early aggregation in bioformulations.
About Malvern Panalytical
Malvern Panalytical’s technical experts are available to support and work with researchers to find the right solution for individual challenges.
Providing agile technology development in partnership with its Bioscience Development Initiative, Malvern Panalytical is always looking for new solutions to enable quicker, easier and more useful analysis.
The company has a suite of instruments that provides access to biophysical information focused on accelerating through characterisation studies, formulation development and quality control.
Malvern Panalytical provides high-quality products and helps clients to achieve maximum return from investment.
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Products and Services
Battery Research and Quality Control Solutions
The age of the battery is well underway. Lithium-ion batteries, for example, have already revolutionized our day-to-day lives – from smart mobile devices to pollution-free electric cars and intelligent power management solutions.
Supporting the Pharmaceutical Industry, 21 CFR Part 11 Compliance Readiness
The purpose of this document is to describe how PANalytical systems support system owners meeting the requirements of the 21 CFR Part 11 regulations issued by the United States’ FDA.
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