Malvern Panalytical Biopharmaceutical and Drug Development

Characterisation technologies

Malvern Panalytical offers characterisation tools for molecular analysis and small drug discovery to help accelerate development for the pharmaceutical industry.

Malvern Panalytical provides characterisation technologies to the drug development industry that advance production processes by increasing productivity and yielding high-quality products at short time-to-market.

The company’s portfolio features a range of automated analysis tools and systems that provide information on key attributes such as particle size, shape, chemical identity, molecular weight, size, and concentration.

These reliable and robust characterisation techniques help drug development companies predict how a product will perform during use and allow for optimisation.

Systems for critical material attribute information

Malvern Panalytical has a wide range of experience in small molecule pharmaceuticals.

Services include systems that provide information on variables identified as critical material attributes (CMA) such as particle size, shape and chemical identity, or molecular weight and size.

Whether characterising particle size and morphological properties of a novel active pharmaceutical ingredient (API) or rheological attributes of a new chemical entity (NCE), Malvern Panalytical can achieve efficiency using common platform technologies.

Small molecule drug discovery and development

Malvern Panalytical’s range of analytical solutions focuses on testing and manufacturing requirements, while taking into account time and cost pressures, as well as sample availability and complexity.

Label-free technologies appeal to researchers across various applications, including biological research, biotherapeutic and small molecule drug discovery and development, immunogenicity studies, vaccine development and quality control.

Label-free techniques are used in the direct study of native molecules, and generate biologically relevant data enabling understanding of molecular interactions without using artificial probes or labels.

Isothermal titration calorimetry for biomolecular interactions

Malvern Panalytical’s MicroCal range includes isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC).

ITC is used in quantitative studies of a range of biomolecular interactions, that work by directly measuring heat that is either released or absorbed during a biomolecular binding event.

By providing a complete thermodynamic profile of the molecular interaction, ITC can explain mechanisms’ underlying interactions, and enable more confident decision-making in hit selection and lead optimisation.

DSC is used to characterise stability of a protein or other biomolecules directly in its native form, and achieves this by measuring heat change associated with the molecule’s thermal denaturation.

Precise and high-quality data obtained from DSC provides vital information on protein stability in process development, and in the formulation of potential therapeutic candidates.

Size exclusion chromatography systems for assessment of product purity

Malvern Panalytical’s analytical toolbox for biopharmaceutical development is tailored to provide trusted solutions such as OMNISEC size exclusion chromatography systems to assess product purity.

The Zetasizer range is also available for sizing and zeta potential analysis for product stability.

The company’s Archimedes and NanoSight systems quantify early aggregation in bioformulations.

About Malvern Panalytical

Malvern Panalytical’s technical experts are available to support and work with researchers to find the right solution for individual challenges.

Providing agile technology development in partnership with its Bioscience Development Initiative, Malvern Panalytical is always looking for new solutions to enable quicker, easier and more useful analysis.

The company has a suite of instruments that provides access to biophysical information focused on accelerating through characterisation studies, formulation development and quality control.

Malvern Panalytical provides high-quality products and helps clients to achieve maximum return from investment.

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Press Release

2020 Forthcoming Events

Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions.

White Papers

Battery Research and Quality Control Solutions

The age of the battery is well underway. Lithium-ion batteries, for example, have already revolutionized our day-to-day lives – from smart mobile devices to pollution-free electric cars and intelligent power management solutions.

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Products and Services


Related Projects

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BESPONSA® is an intravenous infusion indicated for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukaemia (ALL).

17th May 2018

ADYNOVI for the Treatment of Adults and Adolescents with Haemophilia A

ADYNOVI® is an intravenous infusion indicated for the treatment of adults and adolescents with haemophilia A.

2nd May 2018

Hizentra for the Treatment of Patients with CIDP

Hizentra® (immune globulin subcutaneous 20% liquid) is a subcutaneous infusion indicated for the treatment of patients with chronic inflammatory demyelinating polyneuropathy (CIDP).

5th April 2018

Siklos (hydroxyurea) for the Treatment of Children with Sickle Cell Anaemia

Siklos® is an orally administered tablet form of hydroxyurea that is indicated for the treatment of sickle-cell anaemia in paediatric patients aged two years and older.

23rd March 2018

Zinbryta (daclizumab) for the Treatment of Multiple Sclerosis

Zinbryta (daclizumab) is an injectable formulation jointly developed by Biogen and Abbive for the treatment of relapsing forms of multiple sclerosis (MS) in adults.

22nd March 2018

Biktarvy for the Treatment of HIV-I

Biktarvy® is a once-daily regimen indicated for the treatment of HIV-1 infection in adults that were previously not treated with anti-retroviral medicines.

19th February 2018

Endari for the Treatment of Sickle Cell Disease

Endari™ is an orally administered powdered form of amino acid L-glutamine indicated for the treatment of sickle-cell disease.

25th January 2018

SUN-101/eFlow for the Treatment of Chronic Obstructive Pulmonary Disease

SUN-101 (Glycopyrrolate) is an inhalation solution developed by Sunovion Pharmaceuticals as a treatment for patients with moderate to severe chronic obstructive pulmonary disease (COPD).

18th August 2016

Epclusa (Sofosbuvir/ Velpatasvir) for the Treatment of Hepatitis C

Epclusa (Sofosbuvir/ Velpatasvir) is an oral formulation developed by Gilead Sciences for the treatment of 1-6 chronic hepatitis C virus (HCV) infection.

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Idelvion (Coagulation Factor IX (Recombinant), Albumin Fusion Protein) is an injectable formulation developed by CSL Behring, for the treatment of haemophilia B in children and adults.

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Press Release

1st July 2020

Below are the forthcoming shows that will exhibit Malvern’s pharmaceutical solutions.

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14th May 2020

We understand that good communication can ‘bring people together’ even when we are supposed to stay apart from one another.

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31st March 2020

Malvern Panalytical, with Concept Life Sciences (Cheshire, UK), has begun an innovative partnership that unites advanced instrumentation with proficient analytical services for discovery and development.

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4th February 2020

NETZSCH proudly announces the extension of its product range with the Kinexus rotational rheometers and Rosand capillary rheometers, previously developed and distributed by Malvern Panalytical.

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4th November 2019

Here are the forthcoming shows that will exhibit Malvern’s clinical solutions.

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30th October 2019

Dolomite Microfluidics, based in Royston, UK, is a brand of Blacktrace Holdings Ltd, a company which develops and manufactures groundbreaking technologies for applications in biology, chemistry, microfluidics and nanomaterials.

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23rd October 2019

In 2016, Metals and Additives LLC, a leading manufacturer and supplier of powder additives for the battery and plastics industries, purchased the Mastersizer 3000 from Malvern Panalytical.

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4th October 2019

ASTM International, a world-leading standards developer, will hold its board meeting and related events in Boston, Massachusetts, US, on 13-16 October.

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8th July 2019

The New Model in Technology and Engineering (NMiTE) has announced three appointments to its Board of Trustees.

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2nd July 2019

Malvern Panalytical has announced its next round of webinars. Find out more below. If you are interested in attending any of these events, please send an enquiry to find out how to register. 

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24th May 2019

Malvern Panalytical has announced the next wave of webinars, seminars and conferences for June. 

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