SOM Biotech, a biopharmaceutical company specialising in the repositioning of existing drugs for the treatment...
SOM Biotech, a biopharmaceutical company specialising in the repositioning of existing drugs for the treatment of diseases with a high unmet need, announces today that it will present in silico and in vitro results regarding Eravacycline for the treatment of SARS-CoV-2 during a virtual poster presentation at the IDWeek 2020 (21-25 October).
The poster is entitled “Repurposing of Eravacycline for the Treatment of SARS-CoV-2 Infections” and outlines pre-clinical data demonstrating that Eravacycline is a potent inhibitor of the SARS-CoV-2 3CL protease.
Eravacycline was identified using an AI-based screening technology (SOMAIPRO), that analysed a database of clinically tested compounds in search of inhibitors of SARS-CoV2 3CL protease, a viral protein essential for coronavirus infection and replication in host cells.
Covalent docking calculations demonstrated that Eravacycline establishes a covalent bond with Cys145 in the catalytic domain of the SARS-CoV-2 3CL protease. In vitro experiments confirmed inhibition of the protease with an IC50 in the low micromolar range. Eravacycline also inhibits the infection of SARS-CoV-2 in VeroE6 cells and shows no toxicity when applied alone.
The studies also showed that Eravacycline inhibits the 3CL proteases of other related coronaviruses, such as SARS-CoV and MERS-CoV, suggesting that it could be repositioned for the treatment of beta-coronaviruses infections.
“We are pleased to share our in vitro findings on Eravacycline for the treatment of SARS-CoV-2 and to target the hospitalised patients by the virus. The drug accumulates in the lung and has anti-inflammatory and antibacterial activity, therefore, it may play an important role in treating Covid-19 infections, additionally to its inhibitory capacity for virus replication. A Phase 2 clinical trial is planned to prove the efficacy of Eravacycline in hospitalised Covid-19 patients”, says Raul Insa, CEO of SOM Biotech.
Presentation details as follows:
- Session Category: Posters
- Session Title: Covid-19 treatment
- Presenter: Núria Reig
- Poster Board Number: 560 – Repurposing Eravacycline for the Treatment of SARS-CoV-2 Infections
- Abstract Number: 910853
- Location: webpage of congress: https://idweek.org/
TP-434 is a Tetracycline related antibiotic drug approved by the FDA. TP434 is a new antibiotic effective against multidrug-resistant gram-negative pathogens. Tetracycline antibiotics are protein synthesis inhibitors, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 16S rRNA of 30S ribosomal subunit in the mRNA translation complex.
About SOM Biotech
SOM Biotech, established in 2009, is a biopharmaceutical company based in Barcelona, Spain. SOM has an extensive portfolio of products that includes drugs for orphan diseases including TTR Amyloidosis, Huntington’s disease, Tardive Dyskinesia, Phenylketonuria, Niemann-Pick C, Glioblastoma and Parkinson’s disease. The company engages in the accelerated discovery of therapies through a proprietary artificial intelligence-based computational technology (SOMAI PRO) and develops strategic partnerships with major research centres and pharmaceutical companies.
The current Covid-19 pandemic situation has shown that repurposing drugs can be crucial for delivering...
SOM Biotech Announces in Vitro Confirmation of Drug Candidates for Covid-19 in Collaboration with Ewha Woman’s University
SOM Biotech, a clinical-stage drug discovery and development company, announces the in vitro validation of...
Unique advantages of SOMAI PRO include identification of new mechanisms of action of drugs (biological...