Bachem – Your Partner for Opioid Peptides

Several families of endogenous opioid peptides, the endorphins, enkephalins and dynorphins, have been identified in the mammalian central nervous system. The peptides of these families contain an N-terminal Tyr-Gly-Gly-Phe- sequence but are derived from different precursor proteins: proopiomelanocortin (POMC), proenkephalin (PENK) and prodynorphin (PDYN). Proteolytic processing of POMC results in the generation of ß-endorphin. Processing of PENK yields Met-enkephalin and Leu-enkephalin. Dynorphin A and B are derived from PDYN.

An additional family of endogenous opioid peptides is represented by the endomorphins. This family consists of endomorphin-1 (H-Tyr-Pro-Trp-Phe-NH2) and -2 (H-Tyr-Pro-Phe-Phe-NH2).

Endogenous opioid peptides can be produced by neuronal and non-neuronal tissue. They act via opioid receptors (mu, kappa, delta). ß-endorphin preferentially signals through mu and delta receptor subtypes, endomorphins through mu, Met- and Leu-enkephalin through delta receptors. Dynorphin A and B show selectivity for the kappa receptors.

Peptides

• Dynorphin, analogs and sequences
• Endomorphins
• Endorphins, analogs and fragments
• Enkephalins and proenkephalins

Bachem also offers a wide range of immunology products.

Immunology products

• Dynorphins and fragments
• Endomorphins
• Endorphins
• Enkephalins

Many of our opioid peptides are also offered as tracers.

• 125I-labelled peptides

For additional information on these and many other biologically active peptides and immunology products please visit our website.