Bachem – Your Partner for Bioactive Peptides

Thymosin β4 is a 43 amino acid peptide. It is the most abundant member of the β-thymosin family in mammalian tissue and is regarded as the main intracellular G-actin sequestering peptide. Thymosin β4 has multiple biological activities including prevention of apoptosis, reduction of inflammation, and promotion of angiogenesis and cell migration. Due to its role in protection and regeneration of injured or damaged tissue thymosin β4 has received considerable interest as a potential therapeutic agent. Most recently, Xiong et al. demonstrated that delayed administration of thymosin β4 significantly improved histological and functional outcomes in rats with traumatic brain injury.

Bachem offers:

Peptides

  • H-2608 Thymosin β4 (human, bovine, horse, rat); also available as cGMP API
  • H-1156 Ac-Ser-Asp-Lys-Pro-OH (AcSDKP)
  • H-2926 Thymosin β4 (16-38)
  • H-2928 Thymosin β10 (human, rat)
  • H-6945 Thymosin α1 (Thymalfasin); also available as cGMP API
  • H-6028 Thymosin α1 (deacetylated) (human, bovine, mouse, rat)

Immunology products

Thymosin β4 (human, bovine, horse, rat) host: rabbit.

  • S-1298 EIA kit, high sensitivity, CE-marked
  • T-4847 purified antiserum – IgG
  • T-4848 undiluted antiserum for immunohistochemistry

Thymosin a1, host: rabbit.

  • S-1312 EIA kit, high sensitivity, CE-marked
  • S-6002 fluorescent peptide enzyme immunoassay kit, CE-marked
  • T-4856 purified antiserum – IgG

For additional information on these and many other biologically active peptides and immunology products please contact us or visit our website.

References

  • D. Crockford, Ann. N. Y. Acad. Sci. 1112, 385 (2007)
  • N. Smart et al., Ann. N. Y. Acad. Sci. 1112, 171 (2007)
  • H.G. Mannherz and E. Hannappel, Cell Motil. Cytoskeleton 66, 839 (2009)
  • P.R. Riley and N. Smart, Biochem. Soc. Trans. 37, 1218 (2009)
  • J. Zhang et al., Neuroscience 164, 1887 (2009)
  • S.P. Dunn et al., Arch. Ophthalmol. 128, 636 (2010)
  • Y. Xiong et al., J. Neurosurg. Epub ahead of print (2010)

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