Originally published by Elsevier Journals on 24 May 2011, this white paper outlines an open-label, randomised, single-dose, parallel-group study of the pharmacokinetics of oral cyanocobalamin formulated with Sodium N-[8-(2-hydroxy benzoyl) amino] caprylate (SNAC).

Vitamin B12 deficiency may be caused by inadequate dietary intake or by conditions that result in malabsorption. Usually in the form of cyanocobalamin, crystalline vitamin B12 is administered parenterally or orally for the treatment of deficiency states.

Intramuscular administration is widely accepted as a treatment method and oral B12 supplements are also used but are considered less reliable.

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