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February 18, 2022

US accounts for 20.1% share of global clinical trial activity in 2021

By Carmen

The US has accounted for a 20.1% share of the global clinical trials activity in 2021, registering a decrease when compared with the last ten-year average of a 24.4% share, according to GlobalData.

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Industry sponsored trials outnumber non-industry sponsored trials in US

Industry sponsored trials held a 65.2% share of all the clinical trials in the US in 2021, when compared with the ten-year average of 63.6%. Non-industry sponsored trials accounted for a 34.8% share in 2021 as against the average of 36.4% in the last ten years.

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Top therapy areas for industry sponsored clinical trials in US

Oncology was the leading therapy area for industry sponsored clinical trials in the US in 2021 with a 34.9% share, as against a five-year average of 36.3% and a ten-year average of 33.4%.

Central Nervous System held a 15.5% share in 2021, over a five-year average of 14.8% and a ten-year average of 15.4%.

Infectious Disease held a 12.9% share in 2021, compared to a five-year average of 10.0% and a ten-year average of 10.9%. Immunology held a 6.5% share in 2021, as against a five-year average of 6.4% and a ten-year average of 6.5%.

Gastrointestinal held a 6.3% share, over a five-year average of 6.3% and a ten-year average of 5.7%.

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Top therapy areas for non-industry sponsored clinical trials in US

Oncology was the leading therapy area for non-industry sponsored clinical trials in the US in 2021 with a 31.4% share, as against a five-year average of 30.8% and a ten-year average of 34.5%.

Central Nervous System held a 28.4% share in 2021, over a five-year average of 29.1% and a ten-year average of 31.2%.

Infectious Disease held an 11.2% share in 2021, compared to a five-year average of 10.7% and a ten-year average of 11.0%. Cardiovascular held a 7.6% share in 2021, as against a five-year average of 8.5% and a ten-year average of 9.4%.

Metabolic Disorders held a 6.2% share, over a five-year average of 6.7% and a ten-year average of 7.9%.

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Phase II trials lead industry sponsored clinical trials in US in 2021

Phase II trials held a 45.9% share of industry sponsored clinical trials in the US in 2021, over a five-year average of 43.3% and a ten-year average of 41.5%.

Phase I trials held a 25.7% share in 2021, as against a five-year average of 26.5% and a ten-year average of 27.1%. Phase III trials held a 21.1% share in 2021, compared to a five-year average of 22.7% and a ten-year average of 22.9%.

Phase IV trials held a 7.3% share in 2021, over a five-year average of 7.5% and a ten-year average of 8.5%.

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Phase II trials lead non-industry sponsored clinical trials in US in 2021

Phase II trials held a 46.6% share of non-industry sponsored clinical trials in the US in 2021, over a five-year average of 47.0% and a ten-year average of 49.0%.

Phase I trials held a 25.0% share in 2021, as against a five-year average of 23.6% and a ten-year average of 22.9%. Phase IV trials held a 19.1% share, compared to a five-year average of 20.1% and a ten-year average of 19.0%.

Phase III held a 9.3% share in 2021, over a five-year average of 9.2% and a ten-year average of 9.1%.

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Methodology:

The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.

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