Adagio commenced the EVADE trial on obtaining blinded data from Phase I clinical trial in healthy subjects. Credit: Klaus Hausmann from Pixabay.

The global, multi-centre, double-blind, placebo-controlled trial will analyse a single dose of ADG20 administered intramuscularly in two independent cohorts, post-exposure and pre-exposure prophylaxis.

The first cohort will enrol people exposed to a Covid-19 patient while the second cohort will involve people at increased risk for infection or poor response to vaccine.

EVADE will be carried out at over 100 sites across the globe and will include areas with an increased prevalence of SARS-CoV-2 virus variants.

Prevention of lab-confirmed, symptomatic Covid-19 will form the primary efficacy endpoint in the two cohorts.

Adagio commenced the EVADE trial after obtaining blinded data from ADG20’s first-in-human, randomised, placebo-controlled Phase I clinical trial in healthy subjects.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The ongoing Phase I trial is analysing the safety, tolerability, pharmacokinetics and serum SARS-CoV-2 neutralising antibody levels of different doses of the antibody treatment.

According to preliminary data, a single intramuscular ADG20 dose was well-tolerated at doses up to 600mg and its pharmacokinetic profile support an extended serum half-life, which can potentially offer protection from Covid-19 for up to a year.

Also, initial ADG20 serum virus-neutralising activity against SARS-CoV-2 is comparable to peak serum neutralising antibody titers observed in people who received a mRNA Covid-19 vaccine, Adagio said .

Adagio Therapeutics chief medical officer Lynn Connolly said: “Based on its potent and broad activity and extended duration of effect in preclinical models, we believe that ADG20 has the potential to provide both rapid protection in the face of a known, recent exposure to an individual with SARS-CoV-2 infection as well as durable protection over several months, including for individuals who are unlikely to have a sufficiently protective immune response to vaccines.”

After assessing data from the first 200 adult subjects in the Phase II part of the trial, Adagio anticipates enrolling adolescents and pregnant women in the Phase III part.