Atopic dermatitis of the flexure crease of the elbow. Credit: James Heilman.

MorphoSys and Galapagos have commenced a Phase l trial to evaluate MOR106 for the treatment of moderate-to-severe atopic dermatitis.

The trial features a parallel-design and will be conducted in two parts.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

In part one, healthy subjects will receive different single doses of MOR106 administered subcutaneously or intravenously. It will feature a single-centre, randomised, open-label design.

Part two will be a multiple centre, randomised, placebo-controlled, multiple-dose study. It will include patients with moderate-to-severe atopic dermatitis who will receive a subcutaneous dose of MOR106 for 12 weeks.

MorphoSys chief development officer Dr Malte Peters said: “This route of subcutaneous administration is widely used for the treatment of chronic skin diseases, and we intend to evaluate it in this study with the goal of providing support for the further clinical development of MOR106.”

“The trial is designed to study MOR106 for the treatment of patients with moderate-to-severe atopic dermatitis.”

MOR106 was developed using MorphoSys’ Ylanthia antibody platform and features a target discovered by Galapagos.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

It is an investigational antibody directed against IL-17C, a cytokine expressed preferentially in the skin.

Galapagos chief medical officer Dr Walid Abi-Saab said: “This study represents the next important step in our strategy to progress MOR106 rapidly in the clinic and is expected to provide additional insights into patient response, while we await the results of our ongoing IGUANA Phase ll trial with MOR106 in atopic dermatitis patients.”

The IGUANA trial was started by MorphoSys and Galapagos in May this year.

The trial is designed to study MOR106 for the treatment of patients with moderate-to-severe atopic dermatitis.

It intends to enrol 180 patients, who will be treated over a 12-week period, with one of three different doses of MOR106 or placebo using two different dosing regimens across various centres in Europe.