The National Institutes of Health (NIH) has reported data from a large clinical trial, which showed that full-dose anticoagulation (blood thinners) lowered the need for vital organ support in moderately-ill, hospitalised Covid-19 patients.

The three trial platforms in five continents in over 300 hospitals were analysing whether full doses of heparin (blood thinners) could provide a greater benefit to treat moderately ill hospitalised adults with Covid-19 versus lower heparin dose given to prevent blood clots in hospitalised patients.

Moderately ill patients are those not in intensive care and who did not receive organ support like mechanical ventilation while being enrolled in the trial.

According to interim results of over 1,000 moderately ill hospitalised patients, full doses of blood thinners, apart from being safe, were superior to the doses usually given to prevent blood clots in hospitalised patients.

This is with respect to the primary endpoint, which is the need for ventilation or other organ supportive interventions.

Furthermore, a trend in possible reduction of mortality was noted and is being further analysed.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The latest results complement the group’s findings reported last month which showed that routine use of full-dose anti-coagulation in critically ill Covid-19 patients in ICU was not beneficial and could be harmful to some patients.

The three trials, REMAP-CAP Therapeutic Anticoagulation, ACTIV-4 Antithrombotics Inpatient and ATTACC, have a goal of analysing full doses blood thinners’ benefit to treating moderately ill or critically ill adult patients hospitalised with Covid-19 versus lower doses.

The University of Manitoba and CancerCare Manitoba, Canada haematologist and critical care physician professor Ryan Zarychanski said: “In a disease with a limited number of effective therapies, our results represent a game-changer that will impact practice for moderately ill hospitalised Covid-19 patients around the world.”