Cellmid Limited has reported positive data from a mouse model diabetic nephropathy study using two anti-midkine antibodies (MK-Ab).
The functional and histological analysis of the study identified that both the MK-Ab antibodies tested had significantly reduced kidney damage and found that the structure of the kidney was conserved in the treated animals.
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The researchers at the Centre for Transplantation and Renal Research (CTRR), based at the Westmead Millennium Institute and University of Sydney, Westmead Hospital, used an Adriamycin-induced mouse model of nephropathy to carry out the study.
According to renal histological assessment, glomerular sclerosis that was 48% in untreated animals was condensed to less than 20% in both MK-Ab treated groups, while interstitial volume reduced from 35% in untreated animals to 12% in both antibody groups.
MK-Ab treatment maintained tubular cell height and preserved kidney function by reducing protein leakage into the urine, said Cellmid.
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Healthy weight gain and reduced mortality were also observed in the MK-Ab treated animals compared to untreated controls.
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By GlobalDataAccording to the data, 6.3% deaths were reported in treated animals before the end of the study, compared to 25% in the untreated animals.
The studies confirmed that anti-midkine antibodies play a prominent role in causing inflammation and damage in a number of kidney disease and injury settings.
Image: Photographs show representative histological sections from treated and untreated mice. Protein casts are bright pink; yellow arrows indicate large protein cast deposits. Photo: Courtesy of Cellmid.
