Belgian biopharmaceutical firm Celyad has commenced a Phase I clinical trial (SHRINK) of its product candidate CYAD-01 (CAR-T NKG2D) for the treatment of patients with metastatic colorectal cancer.
Go deeper with GlobalData
Discover B2B Marketing That Performs
Combine business intelligence and editorial excellence to reach engaged professionals across 36 leading media platforms.
CYAD-01 is a chimeric antigen receptor (CAR) T-cell therapy that is designed to use NKG2D ligands as a target.
The open-label Phase I trial will assess the safety, clinical activity and synergetic effect of various doses of CYAD-01 in combination with a standard chemotherapy called Folfox in patients carrying potentially resectable liver metastases caused by colorectal cancer.
With SHRINK being CYAD-01’s third clinical trial, the product was also investigated in the completed CM-CS1 trial and is currently being evaluated in an ongoing THINK trial.
Celyad CEO Dr Christian Homsy said: “We are happy to start the SHRINK trial as it will allow us to evaluate the efficiency of our promising CYAD-01 therapy in combination with chemotherapy.
US Tariffs are shifting - will you react or anticipate?
Don’t let policy changes catch you off guard. Stay proactive with real-time data and expert analysis.
By GlobalData“Today’s announcement, in conjunction with our ongoing THINK trial and the upcoming LINK study, reaffirms our commitment and dedication to beat cancer with a strong focus on solid tumours.”
Comprising a dose escalation part of around 18 patients and an extension part with approximately 21 subjects, the Phase I trial will include administration of 3×108, 1×109 or 3×109 CYAD-01 at select oncology centres in the country.
Subjects will receive three successive administrations at each dose and at the specified dose, a gap of two weeks will be executed.
SHRINK is said to be based on findings from pre-clinical studies, as well on data from the THINK trial.
Image: Colon cancer with extensive mets to the liver. Photo: courtesy of James Heilman.
