Seattle Genetics and Takeda Pharmaceutical have completed patient enrolment for the Phase III ECHELON-2 clinical trial of ADCETRIS (brentuximab vedotin) to treat CD30-positive mature T-cell lymphoma (MTCL).
The Phase III double-blind, placebo-controlled Echelon-2 study is testing ADCETRIS with cyclophosphamide (C), doxorubicin (H) and prednisone (P) (A+CHP) against cyclophosphamide, doxorubicin, vincristine (O) and prednisone (CHOP) in 452 patients with previously untreated CD30-positive MTCL.
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The patients were randomised to receive the combination therapy of A+CHP and CHOP.
Seattle Genetics clinical development vice-president Naomi Hunder said: “Our goal is to establish ADCETRIS as the foundation of care for CD30-expressing lymphomas and redefine frontline treatment in Hodgkin lymphoma and MTCL through our broad, late-stage clinical development programme currently underway.
“The ECHELON-2 clinical trial represents our fourth phase III study to complete enrolment.”
Hunder added: “The ultimate goal of this phase III trial is to improve outcomes for frontline patients with CD30-expressing MTCL and, if the trial results are positive, to submit data from this trial to regulatory agencies to expand the label for ADCETRIS use in the frontline setting.”
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By GlobalDataADCETRIS is an antibody-drug conjugate (ADC) consisting of an anti-CD30 monoclonal antibody attached by a protease-cleavable linker to a microtubule disrupting agent, monomethyl auristatin E (MMAE), using Seattle Genetics’ proprietary technology.
The ADC uses a linker system to release MMAE after being injected into the CD30-expressing tumour cells.
