Pancreatic cancer has historically presented a poor clinical outlook, offering patients few effective therapeutic options. Because the disease rarely causes early symptoms, diagnoses typically occur at advanced stages, where a dense, fibrous stroma surrounds tumours and shields them from systemic treatment.
Against this backdrop, data from Revolution Medicines Phase III RASolute 302 trial (NCT06625320) showed a near doubling of overall survival (OS) in patients treated with the daily oral RAS(ON) inhibitor Rasonque (daraxonrasib). The US Food and Drug Administration (FDA) approved the drug in August 2026.
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The data showed a median overall survival (OS) of 13.2 months in the investigational arm, compared with 6.7 months in the standard-of-care (SOC) arm.
Although a substantial amount of data has already been released, Revolution presented further findings at the 2026 European Society for Medical Oncology (ESMO) Congress.
Trial investigator Dr Zev Wainberg, a professor of medicine and gastrointestinal medical oncology at UCLA, presented a subgroup analysis stratified by tumour mutational status. For the most common mutation, RAS G12D, which accounted for 43.2% of patients in the study, the overall response rate (ORR) was 32%, compared to 11% in the placebo cohort. In RAS G12V, ORR was 24% compared to 9% in the placebo cohort. OS throughout all of the mutation subgroups favoured Rasonque.
Tango Therapeutics combo improves PFS
Also making headlines at ESMO 2026 is Tango Therapeutics, which previewed its Phase I/II study of vopimetostat, an investigational PRMT5 inhibitor with first- and best-in-class potential, in combination with Revolution Medicines’ Rasonque in patients with MTAP-deleted and RAS-mutant metastatic pancreatic ductal adenocarcinoma.
As of the data cutoff date of 20 August 20, 2026, the study demonstrated an 82% ORR, with median PFS having not yet been reached. The cutoff saw a nine-month PFS rate of 88% in 22 patients with 2L/3L MTAP-deleted/RAS-mutant pancreatic ductal adenocarcinoma who were efficacy-evaluable.
Dr Malte Peters, CEO and president of Tango Therapeutics, said: “It is encouraging to see that the clinical activity and tolerability observed in our initial June 2026 dataset has been confirmed with longer follow-up and in a larger patient population, affirming our belief that the response rate and durability observed with vopimetostat plus Rasonque surpass any published PDAC datasets, even in front-line settings.”
These data prompted Tango to plan a registrational Phase III trial evaluating vopimetostat with Rasonque as a first-line treatment for MTAP-deleted pancreatic cancer, with initiation expected in the first half of 2027.
GlobalData valued the pancreatic cancer market in the eight major markets (8MM: US, France, Germany, Italy, Spain, UK, China, and Japan) at $2.2bn in 2024 and expects the market to increase to $10.2bn by 2034. GlobalData is the parent company of Clinical Trials Arena.
