Acetylon Pharmaceuticals has initiated a Phase I/IIa clinical trial of ACY-1215, an oral Class II histone deacetylase inhibitor, in adults with relapsed and relapsed/refractory multiple myeloma.

The Phase Ia and Ib portions will evaluate the maximum tolerated dose of ACY-1215 as a monotherapy or in combination with bortezomib and dexamethasone, followed by up to five additional sequential cycles of treatment.

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The Phase IIa portion is designed to determine the objective response rate to ACY-1215 in combination dose for up to six 21-day cycles.

The clinical trial is being conducted by Acetylon in partnership with The Leukaemia & Lymphoma Society.

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