Xencor has begun the Phase 1 clinical trial of humanised monoclonal antibody XmAb5871 for the treatment of autoimmune diseases.

XmAb5871 uses a selective dual-targeting mechanism for B cell inhibition by targeting the antigen CD19 and co-engaging CD32b (FcyRIIb), and is designed to help in the suppression of autoimmune response.

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Preclinical studies demonstrated that XmAb5871 suppresses autoimmune response in humanised mouse models of systemic lupus erythematosus, without the depletion of B cells.

The study results suggest that XmAb5871 could be an effective immunosuppressant in multiple indications, including lupus and rheumatoid arthritis.

The endpoints of the Phase I study include safety, pharmacokinetics and a number of biomarkers of immunomodulatory drug activity.

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