View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. Comment
October 24, 2017updated 13 Jul 2022 10:08am

Emerging immune checkpoint targets now being explored in combination trials

GlobalData analysts have identified 18 emerging immune checkpoint targets that are currently in clinical development.

GlobalData analysts have identified 18 emerging immune checkpoint targets that are currently in clinical development. When looking at four solid tumors—bladder cancer, breast cancer, cervical cancer, and colorectal cancer (CRC)—the analysis of Phase I/II to Phase III trials reveals a large majority of emerging immune checkpoint targets being explored in combination.

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

In the figure above, the number of clinical trials exploring immune checkpoint targets for these four indications are presented. Breast cancer and CRC show the highest number of trials, with nine and 10 trials, respectively. In these two solid tumor types, combination trials accounted for more than 85% of clinical trials.

Based on an analysis of GlobalData’s database, the Pharma Intelligence Center, most combination trials include a programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitor. GlobalData anticipates that emerging checkpoint modulators will increase the response rate of current PD-1/PD-L1 inhibitor therapies, with PD-1/PD-L1 inhibitors becoming backbone therapies for most immuno-oncology therapies.

Related Reports

GlobalData (2017). PharmaFocus: Visual Analysis of Immuno-Oncology Development and Opportunities, August 2017, GDHC009PFR.

Related Companies

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Clinical Trials Arena