Fleet Bioprocessing Researches Immunoassay Conjugate Characterisation

Fleet Bioprocessing and research partners LGC and the National Physical Laboratory (NPL) have successfully acquired funding from Innovate UK to investigate faster and more cost-effective techniques for the characterisation of immunoassay conjugates.

Using expertise from LGC on hydrogen/deuterium exchange mass spectrometry (HDX-MS) and ion mobility spectrometry-mass spectrometry (IMS-MS) and from NPL on circular dichroism spectroscopy (CD), Fourier transform infrared spectroscopy (FT-IR) and isothermal titration calorimetry (ITC),  Fleet Bioprocessing is assessing state-of-the-art technologies for characterisation of labelled antibody conjugates for immunoassay use, with the aim of better prediction of how successfully the conjugate would perform in an immunoassay.

This three-month feasibility project will run from January to March 2019, and is intended to identify techniques with potential for further development

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