IPS Therapeutique, Inc.
3201 Jean-Mignault Street
Sherbrooke
Quebec
J1E 4K8
Other
Canada
Cardiovascular Efficacy and Safety Assessment in New Chemical Entities
3201 Jean-Mignault Street,
Sherbrooke,
Quebec,
J1E 4K8 Other,
Canada
IPS Therapeutique (IPST) is a specialized contract research organization that dedicates its expertise, experience and technology to the assessment of cardiovascular efficacy and safety in new chemical entities, from discovery on to regulatory submission.
IPST believes that well-characterized, thoroughly mastered models and techniques hold the key to highly predictive, cost-effective pre-clinical science in a successful drug-development strategy.
Over the last decade, IPST scientists have directed and executed over 1,000 pre-clinical cardiovascular studies, gaining unparalleled experience in strategic planning, study design, experimentation, analysis, interpretation, and presentation of study results.
Sponsor feedback and development successes have highlighted the positive impact that IPST’s scientists can have on drug development programs; their early-stage advice in study design results in optimized experimental outcomes, and their presence at the development team’s table provides the sponsor with immediate expertise in pre-clinical cardiology.
IPST’s assays examine the effect of test articles on the function of native or cloned ion channels (patch-clamp), isolated tissues and perfused organs, and anaesthetized and conscious animals. These assays have been rigorously validated, are fully GLP-compliant and have been designed to fulfill the FDA’s, Health Canada’s, and the European Union’s requirements, while addressing the concerns and suggestions of the ICH S7a & b guidelines. From discovery to IND, or in support of ongoing clinical trials, IPST’s team can assist sponsors worldwide in the assessment of cardiovascular efficacy and safety.
Specialized efficacy and safety services can be executed as screens or in compliance with current GLP guidelines. IPST provides the following services:
Our hERG and ionic current inhibition assays include:
We offer action potential duration (APD) analysis of:
To detect transmural dispersion of repolarization (TDR) IPST performs simultaneous three-point measurement of APDs from perfused ventricular wedges. This is a conclusive indicator of pre-arrhythmic potential.
We can perform cardiac and vascular muscle tension measurement of:
For both paced and spontaneously beating hearts we can perform complete surface ECG analysis and monophasic action potential (MAP) duration, as well as axial and radial ventricular contractility and coronary tension monitoring.
Our in vivo animal models include:
IPST also provides expert consulting in pre-clinical cardiovascular pharmacology and physiology.
3201 Jean-Mignault Street
Sherbrooke
Quebec
J1E 4K8
Other
Canada