The pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Oncology in Pharmaceuticals: Gene therapy for cancers. Buy the report here.

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According to GlobalData’s Technology Foresights, which uses over 756,000 patents to analyse innovation intensity for the pharmaceutical industry, there are 110 innovation areas that will shape the future of the industry.

Gene therapy for cancers is a key innovation area in oncology

Gene therapy modifies an individual’s genes for the treatment of a disease. It works by replacing a disease-causing gene with its healthy copy, or suppressing a disease-causing gene by silencing it. It can also include the introduction of exogenous nucleic acid sequences to modulate gene expression. Gene modified cell-therapies, such as CAR-T and TCR, have established themselves as a new generation of therapies against cancer.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies.  According to GlobalData, there are 140+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of gene therapy for cancers.

Key players in gene therapy for cancers – a disruptive innovation in the pharmaceutical industry

‘Application diversity’ measures the number of different applications identified for each relevant patent and broadly splits companies into either ‘niche’ or ‘diversified’ innovators.

‘Geographic reach’ refers to the number of different countries each relevant patent is registered in and reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.

Patent volumes related to gene therapy for cancers

Company Total patents (2021 - 2023) Premium intelligence on the world's largest companies
Pfizer 226 Unlock Company Profile
Idera Pharmaceuticals 201 Unlock Company Profile
Ionis Pharmaceuticals 127 Unlock Company Profile
Mologen 117 Unlock Company Profile
Curevac 116 Unlock Company Profile
F. Hoffmann-La Roche 97 Unlock Company Profile
Nitto Denko 91 Unlock Company Profile
EnGeneIC 78 Unlock Company Profile
OncoTherapy Science 74 Unlock Company Profile
SBI Holdings 73 Unlock Company Profile
Otsuka Holdings 73 Unlock Company Profile
Novo Nordisk Foundation 72 Unlock Company Profile
Thermo Fisher Scientific 69 Unlock Company Profile
Alnylam Pharmaceuticals 59 Unlock Company Profile
GSK 54 Unlock Company Profile
Adhera Therapeutics 53 Unlock Company Profile
Zoetis 51 Unlock Company Profile
Dynavax Technologies 46 Unlock Company Profile
Kirin Holdings 45 Unlock Company Profile
InDex Pharmaceuticals Holding 45 Unlock Company Profile
Moderna 44 Unlock Company Profile
Gradalis 44 Unlock Company Profile
Centre National de la Recherche Scientifique 43 Unlock Company Profile
TargImmune Therapeutics 42 Unlock Company Profile
AdiuTide Pharmaceuticals 42 Unlock Company Profile
Arrowhead Pharmaceuticals 38 Unlock Company Profile
Changchun Huapu Biotechnology 38 Unlock Company Profile
Daiichi Sankyo 36 Unlock Company Profile
Exicure 36 Unlock Company Profile
OPKO Health 36 Unlock Company Profile
Amgen 35 Unlock Company Profile
Sanofi 35 Unlock Company Profile
Massachusetts General Hospital 34 Unlock Company Profile
MiNA (Holdings) 33 Unlock Company Profile
Regulus Therapeutics 33 Unlock Company Profile
Memorial Sloan Kettering Cancer Center 32 Unlock Company Profile
InteRNA Technologies 30 Unlock Company Profile
Biogenera 30 Unlock Company Profile
Sarepta Therapeutics 29 Unlock Company Profile
Codiak BioSciences 28 Unlock Company Profile
City of Hope 27 Unlock Company Profile
Ministry of Trade and Industry, Singapore 27 Unlock Company Profile
Regeneron Pharmaceuticals 26 Unlock Company Profile
Editas Medicine 26 Unlock Company Profile
PT Soho Global Health Tbk 26 Unlock Company Profile
Wave Life Sciences 26 Unlock Company Profile
Soluventis Nanotherapeutics 25 Unlock Company Profile
Onxeo 25 Unlock Company Profile
Bio-Path Holdings 24 Unlock Company Profile
Yuhan 22 Unlock Company Profile

Source: GlobalData Patent Analytics

Pfizer is one of the leading patent filers for gene therapy for cancers. Pfizer discovers, develops, manufactures, and commercialises biopharmaceuticals. The company offers products to treat various conditions across cardiovascular, metabolic, pain, cancer, inflammation, immune disorders, and rare diseases. In terms of application diversity, Cytlimic is the top company, followed by Tallac Therapeutics and EMulate Therapeutics. By means of geographic reach, Regulus Therapeutics holds the top position. Otsuka and Phigenix stand in second and third positions, respectively.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Pharmaceutical.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.