Alzheimer’s Disease accounted for a 2.8% share of the global clinical trials within the Central Nervous System therapy area in 2021, registering a decrease of 0.2% when compared with the last ten-year average of 3.0% share, according to GlobalData.
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Industry sponsored trials outnumber non-industry sponsored trials for Alzheimer’s Disease
Industry sponsored trials held a 66.7% share of all the clinical trials for Alzheimer’s Disease indication in 2021, registering a decrease of 0.3% when compared with the ten-year average of 67.0%. Non-industry sponsored trials accounted for a 33.3% share in 2021, registering an increase of 0.3% over the ten-year average of 33.0%.
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Top regions of industry sponsored Alzheimer’s Disease trials
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By GlobalDataAsia-Pacific was the top region for industry sponsored Alzheimer’s Disease trials, accounting for a 51.8% share in 2021, when compared with the five-year average of 43.9% and ten-year average of 38.6%.
North America was at the second position with a 51.8% share in 2021, over the five-year average of 49.3% and ten-year average of 47.8%, followed by Europe with a 25.9% share in 2021, as against five-year and ten-year averages of 35.6% and 41.8% respectively.
Middle East and Africa stood fourth with a 4.7% share in 2021, compared with the five-year average of 3.8% and ten-year average of 4.5%, followed by South and Central America with a 4.7% share in 2021, over five-year and ten-year averages of 5.4% and 5.2% respectively.
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The US was the top country for industry sponsored Alzheimer’s Disease trials, accounting for a 50.6% share in 2021, as against the five-year average of 46.6% and ten-year average of 45.7%.
Australia held a 21.2% share in 2021, over the five-year average of 18.3% and ten-year average of 15.9%, followed by China with a 20.0% share in 2021, compared with the five-year and ten-year averages of 12.5% and 7.5% respectively.
Canada held a 15.3% share in 2021, as against the five-year average of 13.7% and ten-year average of 13.7%.
Japan held a 14.1% share in 2021, over the five-year and ten-year averages of 11.5% and 12.7% respectively.
Top regions of non-industry sponsored Alzheimer’s Disease trials
Asia-Pacific was the top region for non-industry sponsored Alzheimer’s Disease trials, accounting for a 45.5% share in 2021 when compared with the five-year average of 44.9% and ten-year average of 42.8%.
North America was at the second position with a 34.1% share in 2021, over the five-year and ten-year averages of 26.6% and 34.0% respectively, followed by Europe with a 15.9% share in 2021, as against the five-year average of 16.0% and ten-year average of 17.1%.
Middle East and Africa stood at the fourth position with a 9.1% share in 2021, compared with the five-year average of 10.8% and ten-year average of 8.6%, followed by South and Central America with a 2.3% share in 2021, over the five-year and ten-year averages of 1.6% and 2.5% respectively.
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The US was the top country for non-industry sponsored Alzheimer’s Disease trials, accounting for a 31.8% share in 2021, as against the five-year average of 25.7% and ten-year average of 30.9%.
China held a 27.3% share in 2021, over the five-year average of 24.0% and ten-year average of 15.1%, followed by Iran with a 9.1% share, compared with the five-year and ten-year averages of 9.8% and 7.0% respectively.
South Korea held a 6.8% share in 2021, as against the five-year average of 1.4% and ten-year average of 3.8%.
Australia held a 6.8% share in 2021, over the five-year average of 2.1% and ten-year average of 2.9%.
Phase I trials lead industry sponsored clinical trials for Alzheimer’s Disease in 2021
Phase I trials held a 52.1% share of industry sponsored clinical trials for Alzheimer’s Disease in 2021, over the five-year average of 54.2% and ten-year average of 55.1%.
Phase II trials held a 27.1% share in 2021, as against the five-year average of 31.0% and ten-year average of 27.9%. Phase III trials held a 16.7% share in 2021, compared with the five-year and ten-year averages of 12.4% and 12.7% respectively.
Phase IV trials held a 4.2% share in 2021, over the five-year average of 2.5% and ten-year average of 4.2%.
Phase II trials lead non-industry sponsored clinical trials for Alzheimer’s Disease in 2021
Phase II trials held a 50.0% share of non-industry sponsored clinical trials for Alzheimer’s Disease in 2021, over the five-year average of 54.7% and ten-year average of 57.0%.
Phase I trials held a 20.8% share in 2021, as against the five-year average of 21.3% and ten-year average of 18.8%. Phase III trials held a 16.7% share, compared with the five-year and ten-year averages of 13.5% and 12.0% respectively.
Phase IV trials held a 12.5% share in 2021, over the five-year average of 10.5% and ten-year average of 12.2%.
Methodology:
The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.
