Depression accounted for an 8.7% share of the global clinical trials within the Central Nervous System therapy area in 2021, registering an increase of 1.3% when compared with the last ten-year average of 7.4% share, according to GlobalData .

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Non-industry sponsored trials outnumber industry sponsored trials for Depression

Industry sponsored trials held a 38.3% share of all the clinical trials for Depression indication in 2021, registering an increase of 5.0% when compared with the ten-year average of 33.3%. Non-industry sponsored trials accounted for a 61.7% share in 2021, marking a decrease of 5.0% over the ten-year average of 66.7%.

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Top regions of industry sponsored Depression trials

Asia-Pacific was the top region for industry sponsored Depression trials, accounting for a 50.0% share in 2021, when compared with the five-year average of 52.4% and ten-year average of 43.0%.

Europe was at the second position with a 26.3% share in 2021, over the five-year average of 29.5% and ten-year average of 35.2%, followed by North America with a 25.0% share in 2021, as against five-year and ten-year averages of 33.4% and 41.0% respectively.

Middle East and Africa stood fourth with a 7.5% share in 2021, compared with the five-year average of 5.1% and ten-year average of 3.9%, followed by South and Central America with a 5.6% share in 2021, over five-year and ten-year averages of 3.8% and 5.7% respectively.

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China was the top country for industry sponsored Depression trials, accounting for a 31.9% share in 2021, as against the five-year average of 30.7% and ten-year average of 18.0%.

The US held a 22.5% share in 2021, over the five-year average of 32.4% and ten-year average of 39.7%, followed by Russia with a 16.3% share in 2021, compared with the five-year and ten-year averages of 9.7% and 12.5% respectively.

Japan held a 6.3% share in 2021, as against the five-year average of 6.5% and ten-year average of 7.8%.

Germany held a 5.0% share in 2021, over the five-year and ten-year averages of 8.9% and 11.0% respectively.

Top regions of non-industry sponsored Depression trials

Asia-Pacific was the top region for non-industry sponsored Depression trials, accounting for a 45.6% share in 2021 when compared with the five-year average of 40.1% and ten-year average of 35.0%.

North America was at the second position with a 20.1% share in 2021, over the five-year and ten-year averages of 25.8% and 30.8% respectively, followed by Europe with a 17.0% share in 2021, as against the five-year average of 13.1% and ten-year average of 14.4%.

Middle East and Africa stood at the fourth position with a 17.0% share in 2021, compared with the five-year average of 20.2% and ten-year average of 19.1%, followed by South and Central America with a 0.4% share in 2021, over the five-year and ten-year averages of 1.4% and 1.9% respectively.

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China was the top country for non-industry sponsored Depression trials, accounting for a 34.4% share in 2021, as against the five-year average of 22.3% and ten-year average of 15.9%.

The US held a 14.7% share in 2021, over the five-year average of 22.6% and ten-year average of 26.4%, followed by Iran with a 14.3% share, compared with the five-year and ten-year averages of 18.4% and 17.3% respectively.

Canada held a 5.0% share in 2021, as against the five-year average of 3.2% and ten-year average of 4.5%.

Australia held a 3.9% share in 2021, over the five-year average of 2.7% and ten-year average of 3.4%.

Phase I trials lead industry sponsored clinical trials for Depression in 2021

Phase I trials held a 64.9% share of industry sponsored clinical trials for Depression in 2021, over the five-year average of 51.2% and ten-year average of 49.0%.

Phase II trials held a 16.7% share in 2021, as against the five-year average of 19.3% and ten-year average of 17.7%. Phase III trials held an 11.3% share in 2021, compared with the five-year and ten-year averages of 19.0% and 22.8% respectively.

Phase IV trials held a 7.1% share in 2021, over the five-year average of 10.6% and ten-year average of 10.5%.

Phase II trials lead non-industry sponsored clinical trials for Depression in 2021

Phase II trials held a 36.9% share of non-industry sponsored clinical trials for Depression in 2021, over the five-year average of 42.7% and ten-year average of 44.4%.

Phase IV trials held a 23.2% share in 2021, as against the five-year average of 25.0% and ten-year average of 27.2%. Phase I trials held a 21.4% share, compared with the five-year and ten-year averages of 11.9% and 10.3% respectively.

Phase III trials held a 18.5% share in 2021, over the five-year average of 20.3% and ten-year average of 18.1%.

Methodology:
The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.