The global clinical trials activity saw a decrease of 1.8% in Q4 2022, when compared with the rolling average of the last four quarters (Q4 2021 to Q3 2022), according to GlobalData.

Of the overall activity, industry sponsored trials accounted for a 54.4% share in Q4 2022, marking an increase of 4.5% in the total share when compared with the four-quarter average.

Non-industry sponsored trials accounted for a 45.6% share of all the clinical trials globally in Q4 2022, marking a decrease of 4.5% in the overall share when compared with the four-quarter average.

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Top therapy areas for industry and non-industry sponsored clinical trials in Q4 2022

Oncology was the leading therapy area for industry sponsored clinical trials in Q4 2022, accounting for a 30.2% share of all trials.

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This was followed by the following therapy areas: Central Nervous System with a 15.9% share, Infectious Disease with a 12.7% share, Metabolic Disorders with a 7.3% share and Gastrointestinal with a 6.5% share.

In the last four quarters, Oncology held a lead over other therapy areas for industry sponsored clinical trials with a 27.3% share, followed by Infectious Disease with a 14.8% share, Central Nervous System with a 14.3% share, Metabolic Disorders with an 8.4% share, and Cardiovascular with an 8.0% share.

Industry sponsored trials activity: 4-Quarter Avg. vs Q4 2022
Therapy Area 4-Quarter Avg. Q4 2022 Activity
Oncology 27.3% 30.2% Increase
Central Nervous System 14.3% 15.9% Increase
Infectious Disease 14.8% 12.7% Decrease
Metabolic Disorders 8.4% 7.3% Decrease
Gastrointestinal 7.2% 6.5% Decrease
Cardiovascular 8.0% 6.4% Decrease
Immunology 5.4% 5.5% Increase
Respiratory 5.8% 4.7% Decrease
Dermatology 5.3% 4.3% Decrease
Musculoskeletal Disorders 4.0% 3.3% Decrease
Ophthalmology 2.9% 3.3% Increase
Hematological Disorders 3.0% 2.9% Decrease
Genito Urinary System And Sex Hormones 2.7% 2.6% Decrease
Genetic Disorders 1.8% 2.2% Increase
Women’s Health 2.0% 1.7% Decrease
Male Health 0.9% 0.8% Decrease
Ear Nose Throat Disorders 1.7% 0.6% Decrease
Hormonal Disorders 0.8% 0.6% Decrease
Mouth and Dental Disorders 0.6% 0.5% Decrease
Non Malignant Disorders 0.3% 0.2% Decrease
Nutritional Disorders 0.3% 0.2% Decrease

Central Nervous System was the leading therapy area for non-industry sponsored clinical trials in Q4 2022, accounting for a 27.7% share of all trials.

This was followed by the following therapy areas: Oncology with a 24.2% share, Cardiovascular with a 10.0% share, Infectious Disease with an 8.6% share, and Gastrointestinal with a 6.5% share.

In the last four quarters, Central Nervous System System held a lead over others for non-industry sponsored clinical trials with an average share of 26.1%, followed by Oncology with a 22.4% share, Infectious Disease with an 11.3% share, Cardiovascular with a 9.1% share, and Gastrointestinal with a 6.7% share.

Non-Industry sponsored trials activity: 4-Quarter Avg. vs Q4 2022
Therapy Area 4-Quarter Avg. Q4 2022 Activity
Central Nervous System 26.1% 27.7% Increase
Oncology 22.4% 24.2% Increase
Cardiovascular 9.1% 10.0% Increase
Infectious Disease 11.3% 8.6% Decrease
Gastrointestinal 6.7% 6.5% Decrease
Metabolic Disorders 5.8% 5.5% Decrease
Musculoskeletal Disorders 5.3% 5.3% Decrease
Women’s Health 4.8% 4.9% Increase
Respiratory 4.0% 3.8% Decrease
Genito Urinary System And Sex Hormones 2.9% 3.5% Increase
Dermatology 3.1% 3.4% Increase
Hematological Disorders 2.9% 3.3% Increase
Immunology 2.9% 3.2% Increase
Mouth and Dental Disorders 2.9% 2.5% Decrease
Ophthalmology 2.0% 1.6% Decrease
Ear Nose Throat Disorders 1.0% 1.2% Increase
Genetic Disorders 0.7% 1.1% Increase
Nutritional Disorders 0.7% 1.0% Increase
Hormonal Disorders 0.8% 0.8% Decrease
Male Health 0.7% 0.5% Decrease
Non Malignant Disorders 0.4% 0.3% Decrease

Top regions in industry and non-industry sponsored clinical trials activity in Q4 2022

Asia-Pacific held the top position for industry sponsored clinical trials activity in Q4 2022 with a 50.3% share, compared to 57.2% in the last four quarters.

North America stood at second place with a 36.8% share in Q4 2022, over 28.6% in the last four quarters, followed by Europe with a 27.6% share in Q4 2022, as against 25.6% in the last four quarters.

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Single country studies held an 83.8% share in industry sponsored clinical trials in Q4 2022 when compared with 86.2% of average recorded in the last four quarters. Multinational trials accounted for a 16.2% share in Q4 2022, as against the four-quarter average of 13.8%.

Asia-Pacific region held the top position in non-industry sponsored clinical trial activity in Q4 2022 with a 57.2% share, over 54.5% in the last four quarters.

North America held the second position with a 19.3% share in Q4 2022, over 14.6% in the last four quarters, followed by Middle East and Africa with a 12.3% share in Q4 2022, as against 17.3% in the last four quarters.

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Single country studies held a 98.9% share for non-industry sponsored clinical trials in Q4 2022, compared to 98.8% in the last four quarters. Multinational trials accounted for a 1.1% share in Q4 2022, as against 1.1% in the last four quarters.

Industry and non-industry sponsored clinical trials by Phase in Q4 2022

Phase II trials outnumbered all other studies with a 37.9% share for industry sponsored trials in Q4 2022, compared to 33.5% average in the last four quarters.

The share of Phase I trials stood at 35.0% in Q4 2022, as against the four-quarter average of 40.4%. Phase III trials held an 18.7% share in Q4 2022, registering an increase of 3.5% over the last four quarters average, followed by Phase IV trials with an 8.4% share in Q4 2022, as against the four-quarter average of 11.0%.

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Phase II trials outnumbered all other trials with a 49.0% share for non-industry sponsored clinical trials in Q4 2022, compared to 45.7% in the last four quarters.

Phase IV trials stood at second place with a 20.4% share in Q4 2022, compared to 21.1% in the last four quarters. Phase III trials held a 15.5% share in Q4 2022, as against 17.0% in the last four quarters, followed by Phase I trials with a 15.1% share in Q4 2022 over 16.2% average recorded in the last four quarters.

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Methodology:
The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.