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  1. Market Data
July 8, 2022

Global clinical trials activity decreases 4.4% in Q2 2022 over 4Q average

By Carmen

The global clinical trials activity saw a decrease of 4.4% in Q2 2022, when compared with the rolling average of the last four quarters (Q2 2021 to Q1 2022), according to GlobalData.

Of the overall activity, industry sponsored trials accounted for a 52.9% share in Q2 2022, marking an increase of 3.0% in the total share when compared with the four-quarter average.

Non-industry sponsored trials accounted for a 47.1% share of all the clinical trials globally in Q2 2022, marking a decrease of 3.0% in the overall share when compared with the four-quarter average.

 
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Top therapy areas for industry and non-industry sponsored clinical trials in Q2 2022

Oncology was the leading therapy area for industry sponsored clinical trials in Q2 2022, accounting for a 31.7% share of all trials.

This was followed by the following therapy areas: Central Nervous System with a 14.0% share, Infectious Disease with a 13.8% share, Cardiovascular with a 7.7% share, and Metabolic Disorders with a 7.4% share.

In the last four quarters, Oncology held a lead over other therapy areas for industry sponsored clinical trials with a 27.7% share, followed by Infectious Disease with a 16.4% share, Central Nervous System with a 14.1% share, Metabolic Disorders with an 8.3% share, and Cardiovascular with a 7.9% share.

Industry sponsored trials activity: 4-Quarter Avg. vs Q2 2022
Therapy Area 4-Quarter Avg. Q2 2022 Activity
Oncology 27.7% 31.7% Increase
Central Nervous System 14.1% 14.0% Decrease
Infectious Disease 16.4% 13.8% Decrease
Cardiovascular 7.9% 7.7% Decrease
Metabolic Disorders 8.3% 7.4% Decrease
Gastrointestinal 6.7% 5.7% Decrease
Respiratory 5.7% 5.2% Decrease
Dermatology 4.9% 4.7% Decrease
Immunology 5.6% 4.6% Decrease
Musculoskeletal Disorders 4.0% 3.5% Decrease
Hematological Disorders 2.7% 3.2% Increase
Genito Urinary System And Sex Hormones 2.8% 2.7% Decrease
Ophthalmology 2.8% 2.6% Decrease
Genetic Disorders 1.6% 2.5% Increase
Ear Nose Throat Disorders 1.6% 1.3% Decrease
Women’s Health 1.9% 1.3% Decrease
Male Health 1.0% 0.7% Decrease
Hormonal Disorders 0.8% 0.6% Decrease
Mouth and Dental Disorders 0.5% 0.4% Decrease
Nutritional Disorders 0.3% 0.3% Decrease
Non Malignant Disorders 0.3% 0.2% Decrease

Oncology was the leading therapy area for non-industry sponsored clinical trials in Q2 2022, accounting for a 25.7% share of all trials.

This was followed by the following therapy areas: Central Nervous System with a 25.6% share, Infectious Disease with an 11.4% share, Cardiovascular with a 9.8% share, and Metabolic Disorders with a 5.9% share.

In the last four quarters, Central Nervous System System held a lead over others for non-industry sponsored clinical trials with an average share of 24.4%, followed by Oncology with a 23.1% share, Infectious Disease with a 14.1% share, Cardiovascular with a 9.0% share, and Gastrointestinal with a 6.5% share.

Non-Industry sponsored trials activity: 4-Quarter Avg. vs Q2 2022
Therapy Area 4-Quarter Avg. Q2 2022 Activity
Oncology 23.1% 25.7% Increase
Central Nervous System 24.4% 25.6% Increase
Infectious Disease 14.1% 11.4% Decrease
Cardiovascular 9.0% 9.8% Increase
Metabolic Disorders 5.5% 5.9% Increase
Gastrointestinal 6.5% 5.6% Decrease
Musculoskeletal Disorders 5.0% 5.5% Increase
Respiratory 4.1% 4.1% Decrease
Women’s Health 4.5% 3.9% Decrease
Immunology 3.2% 2.7% Decrease
Genito Urinary System And Sex Hormones 2.9% 2.6% Decrease
Dermatology 2.8% 2.5% Decrease
Hematological Disorders 3.0% 2.4% Decrease
Mouth and Dental Disorders 2.4% 2.2% Decrease
Ophthalmology 1.9% 1.5% Decrease
Ear Nose Throat Disorders 1.1% 1.3% Increase
Genetic Disorders 0.6% 1.0% Increase
Nutritional Disorders 0.8% 0.9% Increase
Hormonal Disorders 0.9% 0.5% Decrease
Male Health 0.6% 0.5% Decrease
Non Malignant Disorders 0.3% 0.4% Increase

Top regions in industry and non-industry sponsored clinical trials activity in Q2 2022

Asia-Pacific held the top position for industry sponsored clinical trials activity in Q2 2022 with a 52.6% share, compared to 56.0% in the last four quarters.

North America stood at second place with a 32.0% share in Q2 2022, over 30.1% in the last four quarters, followed by Europe with a 28.2% share in Q2 2022, as against 27.4% in the last four quarters.

 
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Single country studies held an 85.3% share in industry sponsored clinical trials in Q2 2022 when compared with 84.8% of average recorded in the last four quarters. Multinational trials accounted for a 14.7% share in Q2 2022, as against the four-quarter average of 15.2%.

Asia-Pacific region held the top position in non-industry sponsored clinical trial activity in Q2 2022 with a 55.5% share, over 51.8% in the last four quarters.

North America held the second position with a 21.6% share in Q2 2022, over 15.8% in the last four quarters, followed by Europe with a 14.1% share in Q2 2022, as against 14.2% in the last four quarters.

 
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Single country studies held a 98.7% share for non-industry sponsored clinical trials in Q2 2022, compared to 99.0% in the last four quarters. Multinational trials accounted for a 1.3% share in Q2 2022, as against 1.0% in the last four quarters.

Industry and non-industry sponsored clinical trials by Phase in Q2 2022

Phase II trials outnumbered all other studies with a 37.7% share for industry sponsored trials in Q2 2022, compared to 34.3% average in the last four quarters.

The share of Phase I trials stood at 35.8% in Q2 2022, as against the four-quarter average of 38.3%. Phase III trials held a 16.0% share in Q2 2022, remaining flat over the last four quarters average, followed by Phase IV trials with a 10.5% share in Q2 2022, as against the four-quarter average of 11.4%.

 
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Phase II trials outnumbered all other trials with a 48.4% share for non-industry sponsored clinical trials in Q2 2022, compared to 42.7% in the last four quarters.

Phase IV trials stood at second place with a 21.1% share in Q2 2022, compared to 22.5% in the last four quarters. Phase I trials held a 17.8% share in Q2 2022, as against 16.0% in the last four quarters, followed by Phase III trials with a 12.8% share in Q2 2022 over 18.8% average recorded in the last four quarters.

 
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Methodology:
The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.

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