The global clinical trials activity saw an increase of 0.1% in Q3 2021, when compared with the rolling average of the last four quarters (Q3 2020 to Q2 2021), according to GlobalData.

Of the overall activity, industry sponsored trials accounted for a 47.1% share in Q3 2021, marking a decrease of 1.6% in the total share when compared with the four-quarter average.

Non-industry sponsored trials accounted for a 52.9% share of all the clinical trials globally in Q3 2021, marking an increase of 1.6% in the overall share when compared with the four-quarter average.

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Top therapy areas for industry and non-industry sponsored clinical trials in Q3 2021

Oncology was the leading therapy area for industry sponsored clinical trials in Q3 2021, accounting for a 30.4% share of all trials.

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This was followed by the following therapy areas: Infectious Disease with a 15.7% share, Central Nervous System with a 13.7% share, Gastrointestinal with a 6.9% share and Cardiovascular with a 6.6% share.

In the last four quarters, Oncology held a lead over other therapy areas for industry sponsored clinical trials with a 27.5% share, followed by Infectious Disease with a 19.2% share, Central Nervous System with a 13.4% share, Metabolic Disorders with a 7.8% share, and Cardiovascular with a 7.3% share.

Industry sponsored trials activity: 4-Quarter Avg. vs Q3 2021
Therapy Area 4-Quarter Avg. Q3 2021 Activity
Oncology 27.5% 30.4% Increase
Infectious Disease 19.2% 15.7% Decrease
Central Nervous System 13.4% 13.7% Increase
Gastrointestinal 6.0% 6.9% Increase
Cardiovascular 7.3% 6.6% Decrease
Metabolic Disorders 7.8% 6.6% Decrease
Immunology 5.2% 5.4% Increase
Respiratory 6.0% 5.1% Decrease
Musculoskeletal Disorders 3.9% 4.1% Increase
Dermatology 4.3% 3.9% Decrease
Hematological Disorders 2.7% 3.0% Increase
Ophthalmology 3.0% 2.7% Decrease
Genito Urinary System And Sex Hormones 2.6% 2.6% Decrease
Genetic Disorders 1.7% 1.9% Increase
Women’s Health 1.9% 1.9% Decrease
Ear Nose Throat Disorders 1.2% 1.3% Increase
Male Health 0.8% 0.8% Decrease
Hormonal Disorders 0.5% 0.6% Increase
Mouth and Dental Disorders 0.6% 0.6% Decrease
Non Malignant Disorders 0.2% 0.5% Increase
Nutritional Disorders 0.4% 0.2% Decrease

Central Nervous System was the leading therapy area for non-industry sponsored clinical trials in Q3 2021, accounting for a 25.2% share of all trials.

This was followed by the following therapy areas: Oncology with a 24.0% share, Infectious Disease with a 13.1% share, Cardiovascular with an 8.9% share, and Gastrointestinal with a 6.6% share.

In the last four quarters, Oncology System held a lead over others for non-industry sponsored clinical trials with an average share of 23.8%, followed by Central Nervous System with a 22.8% share, Infectious Disease with a 17.8% share, Cardiovascular with a 9.1% share, and Gastrointestinal with a 6.5% share.

Non-Industry sponsored trials activity: 4-Quarter Avg. vs Q3 2021
Therapy Area 4-Quarter Avg. Q3 2021 Activity
Central Nervous System 22.8% 25.2% Increase
Oncology 23.8% 24.0% Increase
Infectious Disease 17.8% 13.1% Decrease
Cardiovascular 9.1% 8.9% Decrease
Gastrointestinal 6.5% 6.6% Increase
Metabolic Disorders 5.0% 5.5% Increase
Musculoskeletal Disorders 5.0% 5.2% Increase
Women’s Health 4.1% 4.1% Decrease
Respiratory 4.9% 3.9% Decrease
Dermatology 2.7% 3.0% Increase
Genito Urinary System And Sex Hormones 2.9% 3.0% Increase
Hematological Disorders 2.7% 2.8% Increase
Immunology 3.4% 2.7% Decrease
Mouth and Dental Disorders 2.2% 2.7% Increase
Ophthalmology 1.8% 1.8% Decrease
Ear Nose Throat Disorders 1.0% 1.2% Increase
Hormonal Disorders 0.8% 1.0% Increase
Genetic Disorders 0.6% 0.8% Increase
Male Health 0.5% 0.5% Decrease
Nutritional Disorders 0.7% 0.5% Decrease
Non Malignant Disorders 0.4% 0.2% Decrease

Top regions in industry and non-industry sponsored clinical trials activity in Q3 2021

Asia-Pacific held the top position for industry sponsored clinical trials activity in Q3 2021 with a 47.1% share, compared to 52.8% in the last four quarters.

North America stood at second place with a 34.0% share in Q3 2021, over 33.4% in the last four quarters, followed by Europe with a 32.2% share in Q3 2021, as against 29.1% in the last four quarters.

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Single country studies held an 84.3% share in industry sponsored clinical trials in Q3 2021 when compared with 82.7% of average recorded in the last four quarters. Multinational trials accounted for a 15.7% share in Q3 2021, as against the four-quarter average of 17.4%.

Asia-Pacific region held the top position in non-industry sponsored clinical trial activity in Q3 2021 with a 53.6% share, over 51.4% in the last four quarters.

North America held the second position with a 20.1% share in Q3 2021, over 17.2% in the last four quarters, followed by Middle East and Africa with a 14.6% share in Q3 2021, as against 15.1% in the last four quarters.

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Single country studies held a 99.0% share for non-industry sponsored clinical trials in Q3 2021, compared to 98.7% in the last four quarters. Multinational trials accounted for a 1.0% share in Q3 2021, as against 1.3% in the last four quarters.

Industry and non-industry sponsored clinical trials by Phase in Q3 2021

Phase II trials outnumbered all other studies with a 39.3% share for industry sponsored trials in Q3 2021, compared to 35.6% average in the last four quarters.

The share of Phase I trials stood at 32.2% in Q3 2021, as against the four-quarter average of 35.1%. Phase III trials held a 17.3% share in Q3 2021, registering an increase of 0.6% over the last four quarters average, followed by Phase IV trials with an 11.2% share in Q3 2021, as against the four-quarter average of 12.6%.

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Phase II trials outnumbered all other trials with a 42.1% share for non-industry sponsored clinical trials in Q3 2021, compared to 44.4% in the last four quarters.

Phase IV trials stood at second place with a 22.1% share in Q3 2021, compared to 21.4% in the last four quarters. Phase III trials held a 19.2% share in Q3 2021, as against 18.3% in the last four quarters, followed by Phase I trials with a 16.6% share in Q3 2021 over 15.8% average recorded in the last four quarters.

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Methodology:
The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.