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September 16, 2022

Pain accounts for 45.8% share of global Central Nervous System clinical trial activity in 2021

By Carmen

Pain accounted for a 45.8% share of the global clinical trials within the Central Nervous System therapy area in 2021, registering a decrease of 1.1% when compared with the last ten-year average of 46.9% share, according to GlobalData.

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Non-industry sponsored trials outnumber industry sponsored trials for Pain

Industry sponsored trials held a 20.6% share of all the clinical trials for Pain indication in 2021, registering a decrease of 0.2% when compared with the ten-year average of 20.8%. Non-industry sponsored trials accounted for a 79.4% share in 2021, registering an increase of 0.2% over the ten-year average of 79.2%.

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Top regions of industry sponsored Pain trials

Asia-Pacific was the top region for industry sponsored Pain trials, accounting for a 55.7% share in 2021, when compared with the five-year average of 43.6% and ten-year average of 35.8%.

Europe was at the second position with a 26.2% share in 2021, over the five-year average of 25.4% and ten-year average of 29.8%, followed by North America with a 22.6% share in 2021, as against five-year and ten-year averages of 35.3% and 39.7% respectively.

Middle East and Africa stood fourth with a 3.4% share in 2021, compared with the five-year average of 3.9% and ten-year average of 3.7%, followed by South and Central America with a 2.7% share in 2021, over five-year and ten-year averages of 2.3% and 2.5% respectively.

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China was the top country for industry sponsored Pain trials, accounting for a 34.4% share in 2021, as against the five-year average of 17.8% and ten-year average of 10.0%.

The US held a 20.8% share in 2021, over the five-year average of 33.0% and ten-year average of 37.1%, followed by Russia with a 13.1% share in 2021, compared with the five-year and ten-year averages of 6.9% and 7.8% respectively.

India held a 7.5% share in 2021, as against the five-year average of 7.2% and ten-year average of 6.9%.

Australia held a 5.4% share in 2021, over the five-year and ten-year averages of 5.7% and 5.6% respectively.

Top regions of non-industry sponsored Pain trials

Asia-Pacific was the top region for non-industry sponsored Pain trials, accounting for a 45.7% share in 2021 when compared with the five-year average of 40.8% and ten-year average of 35.2%.

Middle East and Africa was at the second position with a 21.8% share in 2021, over the five-year and ten-year averages of 24.5% and 24.3% respectively, followed by Europe with a 16.2% share in 2021, as against the five-year average of 17.0% and ten-year average of 19.9%.

North America stood at the fourth position with a 14.9% share in 2021, compared with the five-year average of 16.0% and ten-year average of 18.6%, followed by South and Central America with a 1.4% share in 2021, over the five-year and ten-year averages of 2.1% and 2.4% respectively.

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China was the top country for non-industry sponsored Pain trials, accounting for a 22.7% share in 2021, as against the five-year average of 13.7% and ten-year average of 9.8%.

The US held a 13.0% share in 2021, over the five-year average of 13.5% and ten-year average of 15.6%, followed by India with an 11.7% share, compared with the five-year and ten-year averages of 14.5% and 11.1% respectively.

Iran held a 10.2% share in 2021, as against the five-year average of 13.5% and ten-year average of 15.9%.

Egypt held a 9.8% share in 2021, over the five-year average of 8.7% and ten-year average of 5.8%.

Phase I trials lead industry sponsored clinical trials for Pain in 2021

Phase I trials held a 50.4% share of industry sponsored clinical trials for Pain in 2021, over the five-year average of 38.3% and ten-year average of 36.5%.

Phase II trials held a 21.3% share in 2021, as against the five-year average of 27.8% and ten-year average of 26.8%. Phase III trials held a 17.4% share in 2021, compared with the five-year and ten-year averages of 21.7% and 23.3% respectively.

Phase IV trials held a 10.9% share in 2021, over the five-year average of 12.2% and ten-year average of 13.4%.

Phase II trials lead non-industry sponsored clinical trials for Pain in 2021

Phase II trials held a 41.8% share of non-industry sponsored clinical trials for Pain in 2021, over the five-year average of 51.6% and ten-year average of 51.6%.

Phase IV trials held a 27.5% share in 2021, as against the five-year average of 24.6% and ten-year average of 26.9%. Phase III trials held a 17.4% share, compared with the five-year and ten-year averages of 16.5% and 15.8% respectively.

Phase I trials held a 13.3% share in 2021, over the five-year average of 7.2% and ten-year average of 5.7%.

Methodology:  The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.

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