The UK has accounted for a 3.8% share of the global clinical trials activity in 2021, registering a decrease when compared with the last ten-year average of a 5.8% share, according to GlobalData.

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Industry sponsored trials outnumber non-industry sponsored trials in UK

Industry sponsored trials held an 86.4% share of all the clinical trials in the UK in 2021, when compared with the ten-year average of 81.5%. Non-industry sponsored trials accounted for a 13.6% share in 2021 as against the average of 18.5% in the last ten years.

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Top therapy areas for industry sponsored clinical trials in UK

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Oncology was the leading therapy area for industry sponsored clinical trials in the UK in 2021 with a 29.6% share, as against a five-year average of 31.4% and a ten-year average of 30.6%.

Central Nervous System held a 13.0% share in 2021, over a five-year average of 12.6% and a ten-year average of 12.6%.

Infectious Disease held an 11.1% share in 2021, compared to a five-year average of 9.7% and a ten-year average of 10.3%. Respiratory held an 8.4% share in 2021, as against a five-year average of 8.2% and a ten-year average of 8.7%.

Immunology held an 8.1% share, over a five-year average of 7.3% and a ten-year average of 7.3%.

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Top therapy areas for non-industry sponsored clinical trials in UK

Infectious Disease was the leading therapy area for non-industry sponsored clinical trials in the UK in 2021 with a 32.8% share, as against a five-year average of 15.1% and a ten-year average of 15.5%.

Central Nervous System held a 16.8% share in 2021, over a five-year average of 21.6% and a ten-year average of 22.3%.

Oncology held a 16.0% share in 2021, compared to a five-year average of 12.7% and a ten-year average of 16.0%. Cardiovascular held a 14.5% share in 2021, as against a five-year average of 15.6% and a ten-year average of 17.5%.

Musculoskeletal Disorders held an 8.4% share, over a five-year average of 7.0% and a ten-year average of 6.0%.

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Phase II trials lead industry sponsored clinical trials in UK in 2021

Phase II trials held a 38.4% share of industry sponsored clinical trials in the UK in 2021, over a five-year average of 38.5% and a ten-year average of 36.3%.

Phase III trials held a 37.4% share in 2021, as against a five-year average of 36.0% and a ten-year average of 35.9%. Phase I trials held a 17.9% share in 2021, compared to a five-year average of 18.4% and a ten-year average of 18.7%.

Phase IV trials held a 6.3% share in 2021, over a five-year average of 7.0% and a ten-year average of 9.2%.

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Phase II trials lead non-industry sponsored clinical trials in UK in 2021

Phase II trials held a 50.4% share of non-industry sponsored clinical trials in the UK in 2021, over a five-year average of 51.1% and a ten-year average of 45.6%.

Phase III trials held a 23.7% share in 2021, as against a five-year average of 16.6% and a ten-year average of 17.4%. Phase IV trials held a 14.5% share, compared to a five-year average of 24.4% and a ten-year average of 28.9%.

Phase I held an 11.5% share in 2021, over a five-year average of 7.9% and a ten-year average of 8.1%.

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Methodology:

The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.