Histopathology of Alzheimer’s disease. Credit: Mikael Häggström and brainmaps.org/ commons.wikimedia.org.

AC Immune has reported positive initial interim data from the Phase Ib/II ABATE trial of its ACI-24.060 anti-amyloid-beta (Abeta) vaccine in prodromal Alzheimer’s disease (AD) patients.

The randomised, adaptive, placebo-controlled, multicentre, double-blind ABATE study was designed for evaluating the immunogenicity, safety, pharmacodynamic effects, and tolerability of ACI-24.060 in prodromal AD patients and Down syndrome (DS) adult patients.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The findings showed that the ACI-24.060 vaccine elicited an anti-Abeta antibody response in ABATE’s first, low dose cohort of AD patients at week six.

It was also found to be well tolerated and safe till date.

Now, the ABATE study will be expanded to include DS patients and assess higher doses of the ACI-24.060 vaccine in AD patients.

See Also:

AC Immune stated that dosing has now commenced in the ABATE study’s second, higher dose AD cohort, with these initial findings.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The screening of DS participants for the second part of the study is also cleared to begin.

AC Immune chief medical officer Dr Johannes Streffer said: “ABATE’s innovative design includes interim Abeta PET imaging analyses that can be benchmarked against the levels of plaque clearance achieved with clinically-validated monoclonal antibodies.

“This will provide an opportunity for early de-risking of ACI-24.060 and potentially a rapid transition to a pivotal programme.

“Moreover, the inclusion of cohorts of participants with DS in the trial positions us to potentially address the needs of a vastly underserved vulnerable population, virtually all of whom will develop amyloid plaques and AD.”

The company expects to receive further safety and immunogenicity findings from ABATE cohorts in the second half of this year.