Receive our newsletter – data, insights and analysis delivered to you
  1. News
April 19, 2021

Aegis and Entos commence dosing in trial of Covid-19 DNA vaccine

US company Aegis Life has initiated dosing of the first participants in a Phase I/II clinical trial with parent company Entos Pharmaceuticals’ novel DNA Covid-19 vaccine, Covigenix VAX-001, to induce immunity against SARS-CoV-2. 

US company Aegis Life has initiated dosing of the first participants in a Phase I/II clinical trial with parent company Entos Pharmaceuticals’ novel DNA Covid-19 vaccine, Covigenix VAX-001, to induce immunity against SARS-CoV-2.

Using new Fusogenix technology for delivery, Covigenix VAX-001 encodes the SARS-CoV-2 Spike (S) protein.

Aegis Life CEO John Lewis said: “We’re excited that the Phase I/II trials have begun with our Covid-19 DNA vaccine.

“This milestone brings us one step closer to providing this vaccine to people in the US and the rest of the world.”

The trial is being carried out by the Canadian Center for Vaccinology and the IWK Health Centre in Nova Scotia, Canada.

Phase I will assess the safety and immunogenicity of the vaccine while the phase II trial design has a single-dose regimen as Covigenix VAX-001 had shown promising results on administering a single dose in preclinical studies.

Content from our partners
The importance of reference products in biosimilar trials, and how to source them
Africa’s last mile: Building viable vaccine supply chains
Why this global life sciences COO believes relocation to Charleston, SC, was key to achieving next-level success

Furthermore, in preclinical animal studies, the vaccine had induced a strong humoral immunity and a balanced cell-mediated response against SARS-CoV-2.

Aegis focuses on developing, manufacturing and global marketing of novel DNA vaccines using Fusogenix technology.

This technology safely supplies nucleic acid cargo directly inside cells using innovative lipid formulations, making it the best platform for developing and producing numerous doses of safe, stable and efficient vaccines.

In addition, DNA vaccines are stable at room temperature for a month and 4 to 8°C for a year, which would aid in streamlining shipping, storage as well as vaccine distribution.

Aegis and Entos have also developed another DNA vaccine candidate called Covigenix VAX-002.

Covigenix VAX-002 is designed as a pan-coronavirus and emerging variant vaccine, which is currently in preclinical studies.

Aegis is actively pursuing investments from the US and international companies to progress its DNA-based vaccine candidates to late-stage clinical trials for evaluating safety and effectiveness.

On obtaining funds, the company also intends to scale up commercial manufacturing capacity to produce millions of vaccine doses and distribute them to the US and international markets.

Related Companies

Topics in this article:
NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU