View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
February 13, 2020updated 12 Jul 2022 11:57am

US firm Antios Therapeutics begins Phase I trial for ATI-2173

Clinical-stage biopharmaceutical company Antios Therapeutics has initiated its first-in-human Phase I clinical trial for ATI-2173.

Clinical-stage biopharmaceutical company Antios Therapeutics has initiated its first-in-human Phase I clinical trial for ATI-2173.

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

The ATI-2173 is a liver-targeted, orally-administered, small molecule that works against hepatitis B (HBV).

Antios noted that the study is a randomised, double-blind, placebo-controlled single-ascending dose (SAD) study that will be conducted in healthy participants to evaluate the safety, tolerability, efficiency and pharmacokinetic profile of the compound.

HBV infects the liver and causes infectious hepatitis. It spreads from person to person through the sharing of needles or syringes, sexual intercourse, and from mother to baby during birth.

Chronic liver infection is associated with symptoms such as loss of appetite, nausea, vomiting, fatigue, severe abdominal pain, jaundice, dark-coloured urine, and joint pain.

Antios CEO Abel De La Rosa said: “Dosing the first patients with ATI-2173 is a significant milestone for our company and we are very excited to initiate the first-in-human study of our liver-targeted, non-chain terminating, HBV polymerase inhibitor.”

According to the company, this SAD study will be conducted in up to 35 healthy volunteers randomised into five cohorts of seven subjects each.

The company said that a Phase Ib multiple-ascending dose (MAD) trial in HBV-infected participants is intended to start following the SAD and MAD cohorts completion for the Phase Ia trial.

Antios CMO Douglas Mayers said: “We are looking forward to learning more about ATI-2173 in the clinic after obtaining very encouraging preclinical antiviral activity and preclinical safety data for our lead molecule.”

Based in the US, Antios is engaged in the development of innovative therapies to treat viral diseases.

Related Companies

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Clinical Trials Arena