AUTO4 is a TRBC1-targeting CAR T cell therapy used for the treatment of Peripheral T-Cell Lymphoma. Credit: CI Photos /

Autolus Therapeutics has reported positive results from the Phase I/II LibrA T1 study of AUTO4, a TRBC1-targeting CAR T cell therapy, for the treatment of relapsed/refractory TRBC1-positive peripheral T-cell lymphoma (PTCL).

The multi-centre, open-label, single-arm study has evaluated the efficacy and safety of a single dose of AUTO4 administered intravenously to patients with TRBC1-positive selected PTCL, a rare and heterogeneous form of non-Hodgkin lymphoma.

Out of 19 patients enrolled, ten were dosed using manufacturing process A and three using manufacturing process B.

Four out of four patients who were administered with the highest dose tested (450 x 106 cell dose) achieved a response using the original manufacturing process A.

Complete metabolic responses in two out of four patients are being observed at 15 and 18 months post-dosing, respectively.

Median follow-up of less than three months has been determined for the patients treated using Process B and efficacy data is not provided.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

No dose-limiting toxicities were reported in the study.

UCLH, London chief investigator Dr Kate Cwynarski said: “The LibrA T1 study of AUTO4 is a novel approach using a CAR T cell designed to selectively target and eliminate T cells that include the malignant clone, which harbours the TRBC1 receptor while preserving the T cell compartment with the TRBC2 receptor which helps to maintain immune-competence.

“AUTO4 is well tolerated and the data to date in this early phase study are very promising.”

Autolus is also engaged in developing product candidates for treating solid tumours and haematological malignancies.

Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.