Receive our newsletter – data, insights and analysis delivered to you
  1. News
April 5, 2019

Biognosys develops new proteomics technology for clinical trials

Biognosys has developed new label-free proteomics technology that enables clinical researchers to directly measure and quantify thousands of proteins from patient tissues in clinical trials.

The company conducted a mock study that mimicked implementation of discovery proteomics in a clinical investigation framework.

Biognosys obtained 30 FFPE colorectal cancer (CRC) tumour specimen data from the study.

It was representative of samples obtained in clinical trials and has been investigated with the help of a targeted and a discovery proteomic strategy.

Biognosys chief operating officer Dr Claudia Escher said: “We work with many of the most innovative pharma and biotech companies, who use our discovery proteomics services to advance their early-stage research programmes.

“We increasingly see an interest in using our technology further into the clinical trial phase. We are excited about the perspective that discovery proteomics can soon be an integrated part in clinical trials, and Biognosys is dedicated to bring it to the market.”

The data was generated using the data-independent acquisition technology; a label-free mass spectrometric method that combines parallel acquisition of peptide signatures with targeted data analysis.

Content from our partners
Africa’s last mile: Building viable vaccine supply chains
Why this global life sciences COO believes relocation to Charleston, SC, was key to achieving next-level success
Patient-centric pharma logistics: How CRYOPDP delivers hope worldwide

As part of the study, Biognosys identified close to 9,000 proteins with median technical percentage CVs well below 10% to detect subtle changes in protein expression that may occur in tumour tissue.

Biognosys’ study lays the foundation for a discovery proteomics pipeline that can be operated and documented according to GCP guidelines.

It can be applied to support the design of better clinical trials.

Related Companies

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU