Israeli biopharmaceutical firm BioLineRx and Genentech have launched a Phase Ib/II clinical trial of BL-8040 and atezolizumab (Tecentriq) in patients suffering from gastric cancer.

BL-8040 is a short peptide with for targeting CXCR4 chemokine receptor associated with tumour progression, angiogenesis, metastasis and cell survival, while atezolizumab is Genentech’s anti-PDL1 immunotherapy agent.

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The multi-centre, randomised, controlled, open-label Phase Ib/II trial will assess the safety, tolerability, clinical response and various pharmacodynamic parameters of the combination in around 40 subjects.

Patients will be initially administered with a priming monotherapy of BL-8040 injections, followed by the combination, and will undergo several treatment cycles for approximately two years.

"BL-8040 has shown to induce robust mobilisation of immune cells, improve the infiltration of T cells into solid tumours, and affect the immunosuppressive tumour micro-environment."

The trial is part of ongoing clinical cancer immunotherapy collaboration formed in September last year between BioLineRx and Genentech to conduct various Phase Ib/II studies of the combination therapy for treating different types of cancer.

The collaboration forms part of Genentech’s MORPHEUS cancer immunotherapy development platform. The firms performed two prior oncology trials.

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One trial started in July this year for pancreatic cancer and another commenced last month to treat acute myeloid leukaemia (AML).

BioLineRx CEO Philip Serlin said: “We are therefore hopeful that combining atezolizumab with BL-8040 can lead to a significant advancement in the treatment of gastric cancer, and of other solid tumours that are difficult to treat.

“BL-8040 has shown to induce robust mobilisation of immune cells, improve the infiltration of T cells into solid tumours, and affect the immunosuppressive tumour micro-environment.”