BX004 is intended for the treatment of chronic pulmonary infections caused by Pseudomonas aeruginosa in patients with cystic fibrosis. Credit: Billion Photos / Shutterstock.

BiomX has completed the dosing of patients with cystic fibrosis (CF) in Part II of its Phase Ib/IIa clinical trial of BX004 to treat chronic pulmonary infections caused by Pseudomonas aeruginosa.

Part II of the study will assess the efficacy and safety of BiomX’s new phage cocktail BX004 in at least 24 patients with CF.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

They will be randomised into a 2:1 ratio to receive BX004 treatment or placebo.

BiomX CEO Jonathan Solomon said: “BX004 has been designed to address a significant unmet need facing thousands of CF patients who require new treatments to combat persistent and deadly lung infections.

“With patient dosing now complete in Part II of our Phase Ib/IIa study, we remain on track to announce results next month.”

See Also:

In Part I of the study, the microbiologic/clinical activity, pharmacokinetics and safety of BX004 were evaluated in nine CF patients in a single ascending dose and multiple dose design.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The company announced positive results from this part in February.

In August, the US Food and Drug Administration granted fast-track designation to the therapy to treat chronic respiratory infections.

Last June, BiomX announced a collaboration with Boehringer Ingelheim to identify biomarkers for inflammatory bowel disease (IBD).

BiomX agreed to utilise its XMarker microbiome-based biomarker discovery platform for identifying biomarkers for a pathogenic bacterium associated with IBD.