The combination of AB011 and Roche’s atezolizumab will be evaluated in a trial to treat gastric cancer. Credit: Nephron / commons.wikimedia.org.

CARsgen Therapeutics has announced a collaboration agreement with F. Hoffmann-La Roche (Roche) to assess AB011, along with atezolizumab, to treat gastric cancer.

The collaboration will evaluate CARsgen’s investigational drug AB011, Roche’s PD-L1 checkpoint inhibitor atezolizumab, and the standard-of-care chemotherapy combination in gastric or gastroesophageal junction carcinoma patients.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Under the deal terms, Roche will handle the operations and conduct the trial while the costs of the study’s AB011 treatment arms will be shared by both companies.

CARsgen will use its CLDN18.2 IHC test kit for assessing the CLDN18.2 expression in the gastric cancer patients, as part of the clinical collaboration.

CARsgen founder, Board chairman, CEO, and chief scientific officer Dr Zonghai Li said: “We are glad to work with Roche, a global leader in oncology, to explore the potential of AB011 in combination with atezolizumab and chemotherapy for the treatment of gastric cancer.

See Also:

“CLDN18.2 is a promising therapeutic target for the treatment of CLDN18.2 positive solid tumours, including gastric cancer, [and] pancreatic cancer.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“AB011 is an important asset in the CLDN18.2 franchise of CARsgen and is the first monoclonal antibody against CLDN18.2 that received IND clearance in China.”

Through the collaboration, the companies will evaluate the combination that can potentially bring greater clinical benefits to patients with gastric cancer.

The study of the AB011 and atezolizumab combination will be conducted as part of the Morpheus Platform of Roche.

The platform is said to be a collection of Phase Ib/II clinical trials in several cancers, including gastrointestinal cancer, with high unmet clinical needs.