CT1812 is intended for the treatment of early Alzheimer’s disease. Credit: Robert Kneschke/Shutterstock.com.

Cognition Therapeutics and the Alzheimer’s Clinical Trials Consortium (ACTC) have activated the first site for enrolling patients in the Phase II START study of CT1812 to treat early Alzheimer’s disease (AD).

The study will be carried out at around 50 sites in North America including more than 30 premier academic institutions which are part of the ACTC’s network.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Among the 50 sites, the University of Kentucky Sanders-Brown Center on Aging (SBCoA) is the first site activated for enrolment.

The placebo-controlled, randomised study intends to enrol up to 540 adults with early AD and elevated beta-amyloid (Aβ).

Patients will be randomised to receive either daily one dose of CT1812 orally or a placebo for 18 months.

See Also:

Cognition president and CEO Lisa Ricciardi said: “While trials in this patient population are crucial, the long treatment period required to show a change in cognition can be overly burdensome for small biotechnology companies.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“Without the support of the ACTC and the NIA’s $81m grant, we would likely not be in a position to offer these research participants the opportunity to test an oral once-daily medication that may slow the progression of Alzheimer’s disease.

“It is incredibly exciting and humbling to have reached the stage where patient recruitment can finally begin.”

The investigational oral small molecule CT1812 binds to neuron receptors and prevents the toxic effects caused by soluble Aβ oligomers.

So far, more than 200 healthy volunteers and adults with AD or dementia with Lewy bodies were evaluated to assess the tolerability of CT1812. It was found to be consistent throughout the development.

Mild to moderate adverse events were observed with no occurrence of deaths and treatment-related serious adverse events.