Share
eFFECTOR’s CEO Steve Worland said: “We do not see an obvious path forward” to continue developing the drug in this indication. Image credit: Shutterstock/Gajus.

eFFECTOR Therapeutics has discontinued the development of tomivosertib as a frontline treatment for non-small cell lung cancer (NSCLC) following negative topline results.

The Phase II KICKSTART trial was investigating tomivosertib in combination with MSD’s Keytruda (pembrolizumab) in patients with NSCLC with programmed death-ligand 1 (PD-L1) expression in tumours higher than 50%. Patients receiving the combo were compared to those receiving a placebo along with Keytruda.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The US biotech reported the trial did not meet the primary endpoint of hazard ratio for progression-free survival. Additionally, eFFECTOR did not discern a trend favouring tomivosertib for overall survival.

Whilst eFFECTOR’s combo therapy led to modest improvements, there were 67% treatment-emergent adverse events in the tomivosertib treatment arm compared to 37% receiving the placebo combo.

eFFECTOR’s Steve Worland said: “Based on the totality of the data currently available we do not see an obvious path forward to continue developing tomivosertib in frontline NSCLC.”

See Also:

Worland said focus will now shift to the company’s other pipeline candidates, including eIF4A inhibitor Zotatifin for the treatment of breast cancer.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Earlier this month, AstraZeneca reported positive data from its FLAURA2 Phase III clinical trial of Tagrisso (osimertinib) combined with chemotherapy. MAIA Biotechnology also unveiled positive efficacy data from its Phase II THIO-101 clinical trial of THIO sequenced with cemiplimab (Libtayo).

NSCLC is the most common type of lung cancer. In 2024, it is estimated there will be nearly 235,000 new cases of lung cancer.

The NSCLC market is largely dominated by Keytruda, which saw $25bn in global sales last year. Across 15 global markets, the NSCLC market is predicted to reach over $45.4bn in total by 2031, according to a report by GlobalData.

GlobalData is the parent company of Clinical Trials Arena.