Anokion has announced positive data from a completed Phase I trial investigating KAN-101 for coeliac disease treatment.

The trial (NCT04248855), termed ACeD, was a randomised, double-blind, placebo-controlled study that investigated 41 individuals with coeliac disease on a gluten-free diet across two cohorts of single-ascending dose and multi-ascending dose.

Early findings from the study demonstrated safety and tolerance of KAN-101, along with inducing functional tolerance of gliadin-specific T cells following gluten challenge. KAN-101 can specifically target parts of the immune system responsible for gluten immune reaction as opposed to conventional broad-sweeping immunosuppressants.

In the multi-ascending dose segment, patients were administered with KAN-101 on days 1,4, and 7 at dose levels of 0.15, 0.3, and 0.6 mg/kg or placebo. A three-day gluten challenge then followed on day 15.

The recent findings announced by the Swiss company demonstrated that KAN-101 was cleared from systemic circulation within approximately six hours in the multi-ascending cohort, and effects lasted up to three weeks after treatment. KAN-101 also increased gliadin-specific, tetramer+ T cells and, after the gluten challenge, led to a dose-dependent modulation of interleukin-2. 

The company plans to continue with Phase II initiation in 2023, with initial data expected in early 2024.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Coeliac disease is an autoimmune condition that affects around 2 million people in the US, according to the National Institutes of Health. Whilst there is no cure, current treatments explore suppressing immune reactions, managing symptoms, and alleviating long-term health effects. “As a highly burdensome condition with no disease-modifying therapies available today, KAN-101 could be a game changer for patients, with durable treatment effects observed following administration,” said Deborah Geraghty, Ph.D., chief executive officer of Anokion.