Enterin has completed enrolment in the RASMET study analysing the safety, tolerability and efficacy of ENT-01 in patients with Parkinson’s Disease (PD).

The two-stage Phase IIa trial has enrolled a total of 50 patients at multiple sites in the US over a ten-month period.

During the first stage of the trial, single escalating doses of ENT-01 were given to ten patients and titrated to tolerability.

In the second stage, daily escalating doses of ENT-01 were given to 40 patients and titrated to a clinically efficacious or maximum dose, followed by a randomised withdrawal period.

“It could be used to improve some or all Parkinson’s Disease symptoms such as constipation, disturbed sleep and hallucinations.”

The RASMET study examined the safety, tolerability and efficacy of the orally administered synthetic derivative of squalamine, ENT-01, which is not absorbed into the bloodstream of the patients.

The ENT-01 compound acts locally on the enteric nerve cells of the gut, stimulating gut motility and change afferent neural signalling from gut to brain.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

It could be used to improve some or all Parkinson’s Disease symptoms such as constipation, disturbed sleep and hallucinations, as well as modify disease progression.

Enterin noted that synthetic squalamine has recently demonstrated its ability to prevent the buildup and reduce the toxicity of alpha-synuclein, implicated in the pathogenesis and progression of PD.

The compound has also proved its efficiency in displacing alpha-synuclein aggregates from the inner wall of nerve cells, and in preventing the paralysis that develops in C. Elegans worms engineered to produce alpha-synuclein in its muscles.

Enterin is currently in the process of conducting a Phase IIb study for the treatment of patients with PD and constipation in the last quarter of this year.

The company also plans to carry out trial in PD patients with hallucinations, in schizophrenia and in autism in future.