EpicentRx has commenced the Phase I PIRATE clinical trial of its lead small-molecule, RRx-001, in combination with irinotecan and temozolomide to treat recurrent or progressive malignant solid and central nervous system (CNS) tumours in paediatric patients. 

The trial will be carried out by EpicentRx in partnership with the Texas Children’s Cancer Center in Houston, US.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Conceived and developed by the Texas Children’s Cancer Center doctors, the trial will analyse the safety and benefit of RRx-001 to treat paediatric CNS tumours.

It will have subjects aged one to 21 years with recurrent or progressive malignant primary brain or spinal cord tumours and solid tumours, excluding lymphomas.

Various prior trials validate the potential evidence that RRx-001 boosts chemotherapy delivery and uptake in tumours. 

See Also:

In a Phase I G-FORCE trial and a Phase I/II BRAINSTORM trial of adult glioblastoma and brain metastases patients, respectively, RRx-001 was found to be safe and offered clinical benefit.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

EpicentRx CEO Tony Reid said: “We are excited to launch this study with RRx-001 and to establish its role as a potential treatment for paediatric CNS tumours. 

“As clinical trials in adult CNS tumours suggest that RRx-001 may provide benefit in a paediatric population, our collaboration with them is a testament to the commitment of this company to follow the data wherever it leads.”

In July 2020, the company signed a licensing agreement with SciClone Pharmaceuticals International for RRx-001 in Greater China.

An immunotherapeutic acting on the CD47 – SIRPα axis, RRx-001 repolarises tumour-associated macrophages as well as other immunosuppressive cells in the tumour microenvironment to an immunostimulatory phenotype.

It can also boost tumour blood flow to improve the supply of oxygen and delivery of the drug.