View all newsletters
Receive our newsletter – data, insights and analysis delivered to you
  1. News
  2. Company News
February 13, 2019

Exelixis to assess new tumour-targeting candidate in Phase I trial

US-based biotechnology firm Exelixis is set to commence a Phase I clinical trial to evaluate its new compound XL092 intended for the treatment of various cancer types.

Exelixis is set to commence a Phase I clinical trial to evaluate XL092 for the treatment of various cancer types.

Free Whitepaper
img

Unlocking the clinical trial potential of Africa

Ongoing improvements around infrastructure, continued investment, and being home to one of the world’s largest working age populations, means that Africa’s role in the clinical trials market has transformed. In this whitepaper, Oximio outlines the dynamics of today’s clinical trial market in Africa, including the key challenges the region is facing and how sponsors can overcome them to unlock the continent’s growing potential.
by Oximio
Enter your details here to receive your free Whitepaper.

XL092 is an oral tyrosine kinase inhibitor designed by Exelixis to target VEGF receptors, MET and other kinases related to tumour growth and spread.

The US-based biotechnology firm submitted the compound’s investigational new drug (IND) application to the US Food and Drug Administration (FDA) in December last year.

The multi-centre Phase I trial will assess the safety, tolerability and pharmacokinetics of the drug candidate and will be performed in two sections, consisting of dose-escalation and expansion sections.

Patients suffering from advanced solid tumours will participate in the dose-escalation part.

“XL092 is a novel compound that targets key signal transduction pathways in tumours, while potentially addressing tumour-induced immune suppression.”

The primary objective of this portion is to determine a dose for daily oral administration of XL092 that is suitable for further assessment.

Based on the findings from the dose-escalation part of the trial, the expansion portion will be initiated to further study the selected dose in individual tumour cohorts.

The expansion part will evaluate the compound’s safety, tolerability, and initial clinical activity.

Exelixis chief scientific officer and Scientific Strategy executive vice-president Peter Lamb said: “XL092 is a novel compound that targets key signal transduction pathways in tumours, while potentially addressing tumour-induced immune suppression.

“Data from the upcoming Phase II clinical trial will be used to determine the potential for further development of XL092.”

The company partnered with Ipsen in December last year to conduct a Phase III clinical trial (COSMIC-312) of its cabozantinib (cabometyx) therapeutic in combination with atezolizumab (tecentriq) in previously untreated advanced hepatocellular carcinoma (HCC)patients.

Related Companies

Free Whitepaper
img

Unlocking the clinical trial potential of Africa

Ongoing improvements around infrastructure, continued investment, and being home to one of the world’s largest working age populations, means that Africa’s role in the clinical trials market has transformed. In this whitepaper, Oximio outlines the dynamics of today’s clinical trial market in Africa, including the key challenges the region is facing and how sponsors can overcome them to unlock the continent’s growing potential.
by Oximio
Enter your details here to receive your free Whitepaper.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Clinical Trials Arena