FSD Pharma has concluded the first-in-human (FIH) sentinel dosing in a Phase I trial of its neuroprotective compound Lucid-21-302 (Lucid-MS) for the treatment of multiple sclerosis (MS).
Designed as an orally-administered treatment, the first-in-class new chemical entity Lucid-21-302 will be evaluated for its safety and tolerability.
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Functional recovery was observed in the MS experimental animal models administered with Lucid-MS. It also prevented myelin degradation (demyelination) in preclinical models.
Demyelination is said to be a hallmark pathology characteristic of MS, as well as other neurogenerative disorders.
FSD Pharma subsidiary Lucid Psycheceuticals CEO Dr Lakshmi Kotra said: “Dosing the sentinel subject is a major achievement for our team and culmination of more than a decade of very promising research by a seasoned development team passionate about changing the future treatment paradigm for patients dealing with the debilitating effects of MS.
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“Current MS treatments are immunomodulatory and include repeated subcutaneous or intramuscular injections for treating the symptoms of MS. We envision a day where an oral medication will protect or even help repair myelin in the central nervous system, a hallmark feature of the disease.
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By GlobalData“We are optimistic Lucid-MS has this type of paradigm-shifting potential and the sentinel dosing is a critical step in advancing this pipeline forward.”
MS is said to be a chronic inflammatory and degenerative disorder of the central nervous system and existing treatments reduce the relapse rate.
