View all newsletters
Receive our newsletter – data, insights and analysis delivered to you
  1. News
September 21, 2021

Gritstone starts Phase I dosing of second-gen mRNA Covid-19 vaccine

The trial will test the safety, tolerability and immunogenicity of two dose levels of the vaccine given as a booster to Vaxzevria.

Clinical-stage biotech company Gritstone has dosed the first participants in a Phase I clinical trial of its second-generation, self-amplifying mRNA (SAM) Covid-19 vaccine.

Named GRT-R910, the vaccine is expected to boost and expand first-generation Covid-19 vaccines’ immunogenicity in people aged 60 years and above.

The single-centre Phase I trial is being performed in alliance with The University of Manchester and Manchester University NHS Foundation Trust in the UK.

GRT-R910 utilises a SAM vector formulated with lipid nanoparticles to deliver antigens against both SARS-CoV-2 spike protein and highly conserved viral protein regions consisting of T cell epitopes.

The self-amplification, prolonged duration and extent of antigen generation with SAM vaccines could enable a decrease of vaccine doses or avoid repeat administrations, the company said.

Gritstone added that GRT-R910 may trigger robust, sustainable and wide immune responses against SARS-CoV-2 variants.

Gritstone co-founder, president and CEO Andrew Allen said: “Our SAM COVID vaccine is designed to drive robust CD8+ T cell responses, in addition to strong neutralising antibody responses, offering the promise of longer-lasting immunity, especially in more vulnerable populations.

“Additionally, since viral surface proteins like the spike protein are evolving and sometimes partially evading vaccine-induced immunity, we designed GRT-R910 to have broad therapeutic potential against a wide array of SARS-CoV-2 variants by also delivering highly conserved viral proteins that may be less prone to antigenic drift.”

Sponsored by Gritstone, the open-label, dose-escalation Phase I trial will initially enrol 20 participants.

It will evaluate GRT-R910’s ability to boost the immunogenicity of AstraZeneca’s first-generation Covid-19 vaccine, AZD1222 (Vaxzevria), in healthy adults aged 60 years and above.

The trial will check the dose, safety, tolerability and immunogenicity of two GRT-R910 dose levels at a minimum of four months following the second administration of the initial vaccine.

Preliminary data from the Phase I trial are anticipated in the first quarter of next year.

In March 2021, the company began dosing in GRT-R910’s Phase I study supported by the US National Institute of Allergy and Infectious Diseases (NIAID).

Related Companies

Free Report
img

Reshape regional strategies to navigate global uncertainties

The COVID-19 crisis triggered one of the worst peacetime recessions globally. Even as several economies tread the path to recovery, the surge in COVID-19 cases and emergence of new variants, coupled with geopolitical tensions, will continue to cloud the global outlook.  The Global Risk report uses GlobalData’s proprietary Country Risk Index to determine the existing and future level of global risk by assessing over 50 key indicators, including:  
  • Macroeconomic 
  • Political 
  • Social
  • Technological 
  • Environmental 
  • Legal 
Use our Country Risk Index scores to help you understand future global risk and determine your business strategies, growth plans and investment portfolios. 
by GlobalData
Enter your details here to receive your free Report.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU