This image has an empty alt attribute; its file name is Cytiva-CTA-1024x101.png

Horizon Therapeutics has dosed the first participant in a Phase I trial of HZN-457, previously called ARO-XDH, to treat gout, a painful form of inflammatory arthritis.

The randomised, placebo-controlled Phase I trial has been designed for evaluating the pharmacokinetics, tolerability, pharmacodynamics, and safety of HZN-457, a development-stage medicine, for gout treatment.

A small interfering RNA (siRNA) candidate, HZN-457 has been designed for the treatment of gout by silencing liver xanthine dehydrogenase.

The company stated that the HZN-457 development is part of a global collaboration and license deal, which it signed with Arrowhead Pharmaceuticals last year.

Horizon Therapeutics research and development executive vice-president Elizabeth Thompson said: “As a clinical and commercial leader in gout, Horizon understands the critical need to develop innovative approaches and advance novel treatments to reach more patients who live with this disease.

“The HZN-457 Phase I clinical trial marks an important milestone for Horizon to advance our research and development in this space, fostered by our partnership with Arrowhead.”

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The clinical trial is anticipated to enrol up to 56 healthy volunteers sequentially into the ascending dose cohorts. They will be given HZN-457 subcutaneously as a single dose.

Safety and tolerability comprise the primary endpoint of the trial.

Changes from baseline in uric acid levels and evaluation of plasma and urine pharmacokinetic parameters are the trial’s secondary endpoints.

In March last year, the company enrolled the first patient in a clinical trial of Krystexxa (pegloticase injection) and methotrexate to treat chronic gout refractory to conventional therapy, also known as uncontrolled gout.

Cell & Gene Therapy coverage on Clinical Trials Arena is supported by Cytiva.

Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.