View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
December 6, 2021updated 11 Jul 2022 2:16pm

Hummingbird begins dosing with HMBD-001 in Phase I cancer trial

The trial will assess safety, tolerability, pharmacodynamics and pharmacokinetics of the drug to treat solid tumours.

Hummingbird Bioscience and Cancer Research UK have dosed the first subject in a Phase I trial of the company’s monoclonal antibody drug candidate, HMBD-001, to treat individuals with advanced HER3-expressing solid malignancies in the UK.

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

An anti-HER3 antibody, HMBD-001 leverages a differentiated mechanism of action to potentially hinder the development of all active HER3 dimers, irrespective of NRG1 ligand binding or overexpression of HER2/EGFR.

The trial is sponsored and run by the Centre for Drug Development of the Cancer Research UK and The Institute of Cancer Research, London.

It will analyse the safety, tolerability, pharmacodynamics, pharmacokinetics and detect initial evidence of the antibody’s activity in subjects with advanced HER3-expressing solid malignancies, comprising NRG1 fusion-driven tumours.

Hummingbird Bioscience chief scientific officer Dr Jerome Boyd-Kirkup said: “Dosing of the first patient in the clinical trial of HMBD-001, Hummingbird’s most advanced programme, marks the beginning of a potentially transformative approach to treating HER3-driven cancers.

“Hummingbird Bioscience is dedicated to discovering and developing important medicines for cancer and autoimmune disease with our unique Rational Antibody Discovery platform.”

Preliminary results from the Phase I dose-escalation trial are anticipated in the second half of next year.

In preclinical models, HMBD-001 showed greater affinity and potently hindered tumour growth versus other current anti-HER3 antibodies.

Cancer Research UK Centre for Drug Development director Dr Nigel Blackburn said: “Although HER3 was discovered over 30 years ago, no therapies able to block its cancer-promoting action have been approved.

“Hummingbird Bioscience has taken fresh aim at a difficult drug target and has come up with a novel, potentially transformative antibody for cancer patients who desperately need new treatments.”

In August 2019, Hummingbird and Cancer Research UK partnered to develop HMBD-001 for the treatment of HER3-driven cancer patients.

Related Companies

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Clinical Trials Arena