US-based biotechnology company Ideaya Biosciences has reported positive interim data from a Phase II trial of IDE397 to treat methylthioadenosine phosphorylase (MTAP) deletion urothelial and non-small cell lung cancer (NSCLC).

The study evaluated a 30mg once-daily dose of IDE397 in 18 evaluable patients, who included individuals with urothelial cancer, adenocarcinoma NSCLC and squamous NSCLC.

Preliminary results indicate an overall response rate of 39% and disease control rate of 94%, with 78% of patients experiencing tumour shrinkage.

The reported clinical efficacy and tolerability data are preliminary and based on an investigator review from an unlocked database as of 21 June.

The RECIST 1.1 evaluation showed one complete response and six partial responses out of the 18 evaluable patients.

In addition, the trial saw a circulating tumour DNA molecular response rate of 81% among patients.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Its swim lane plot by CT-scan evaluation and initial durability assessment showed that 11 patients are still on treatment, with five maintaining their RECIST 1.1 response.

The treatment showed a favourable adverse event profile with no drug-related serious adverse events observed at IDE397 30mg once-a-day expansion dose.

IDEAYA Biosciences chief medical officer Dr Darrin Beaupre said: “We are highly encouraged by the preliminary clinical efficacy and favourable safety profile observed with IDE397 at the 30mg once-a-day expansion dose, including multiple partial responses and one complete response by RECIST 1.1 in MTAP-deletion urothelial and lung cancer patients.

“In addition, at this expansion dose, we observed a favourable adverse event profile with no drug-related serious adverse events and mid-single digit percent Grade III or higher drug-related adverse events, which we believe has the potential to enable longer duration dosing as well as combinations.”

Last month, IDEAYA dosed the first subject in its Phase I trial of IDE397 plus Trodelvy in patients with MTAP-deletion bladder cancer.