View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. News
October 14, 2021updated 11 Jul 2022 2:22pm

Immune-Onc doses first patient in Phase I solid tumour treatment trial

The dose-escalation trial will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of IO-108.

Immune-Onc Therapeutics has dosed the first subject in the Phase I clinical trial of IO-108 to treat solid tumours.

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

A new antagonist antibody, IO-108 acts on the myeloid checkpoint Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2 / ILT4).

The multicentre, dose-escalation Phase I trial will analyse the tolerability, safety, pharmacokinetics, and pharmacodynamics of IO-108 as a single agent and along with pembrolizumab.

Pembrolizumab is an anti-programmed cell death protein 1 (PD-1) antibody.

The trial will also analyse biomarkers to facilitate a mechanistic interpretation of clinical data and inform upcoming trials.

It might also aid in detecting initial efficacy signals, the company noted.

Immune-Onc plans to evaluate the efficacy, safety and tolerability of IO-108 alone and with pembrolizumab in indication-specific expansion groups on determining the recommended dose for the Phase II trial.

The company anticipates reporting top-line trial results next year.

Immune-Onc chief medical officer Paul Woodard said: “The first patient dosed in our Phase I clinical trial for IO-108 represents a critical milestone in advancing the development and understanding of Immune-Onc’s novel myeloid checkpoint inhibitors targeting the LILRB family of immune inhibitory receptors.

“We believe our scientific platform holds vast promise and today’s news reflects our commitment to rapidly advancing programs in our portfolio that have the potential to improve outcomes for cancer patients.”

On treating several primary human immune cell systems having myeloid cells with IO-108 in preclinical studies, improved proinflammatory responses to various stimuli pertinent to anti-tumour immunity were observed.

Immune-Onc noted that IO-108 monotherapy could reverse the anti-inflammatory myeloid cell phenotype caused by ‘tumour conditioning’.

IO-108 also boosts monocyte differentiation into pro-inflammatory dendritic cells.

The clinical-stage cancer immunotherapy firm focuses on discovering and developing new myeloid checkpoint inhibitors for the treatment of cancer.

Related Companies

Free Case Study
img

Direct-to-Patient Trials: How IRT Plays an Important Role in Bellerophon's Direct-to-Patient Trials

As the industry strengthens its focus on patient centricity, Direct-to-Patient clinical trials have emerged as a popular trial design that have the potential to increase patient recruitment and retention. IRT plays a crucial role in the success of a Direct-to-Patient trial. Because drug supplies are being managed and shipped from distribution facilities directly to patients’ homes, a sponsor must have a high-quality system in place to accurately track the chain of custody, ensure patient-blinding and handle other logistical challenges. What You Will Learn Benefits and challenges associated with the Direct-to-Patient model Bellerophon's top considerations when implementing this trial design How IRT can equip study teams to successfully track chain of custody, ensure patient blinding, and handle logistical challenges
by Suvoda
Enter your details here to receive your free Case Study.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. Key drug pipeline and competitive landscape changes based on the latest clinical activity, sent every Tuesday. Curated analysis and data-driven insights on clinical trials strategy and operations, sent every Thursday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Clinical Trials Arena