Immusoft’s newly engineered B cell therapy does not require chemotherapy or immunosuppression. Credit: Likoper / Shutterstock.com.

Immusoft has dosed the first subject with its investigational engineered B cell therapy, ISP-001, in a human Phase I clinical trial of mucopolysaccharidosis type I (MPS I), a rare genetic disease.

The first patient was dosed at M Health Fairview University of Minnesota Medical Center in the US.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

This patient was administered the investigational therapy without requiring a preconditioning treatment, which is needed for gene-modified stem cells or immunosuppression, required for systemic virus-delivered gene therapy. 

Preconditioning comprises myeloablative chemotherapy, which can lead to infertility, hair loss and nausea, as well as a long stay at the hospital. It could also cause life-threatening infections. 

Immunosuppression is linked to significant morbidity and can intensify infection risk. 

See Also:

Immusoft’s new engineered B cell therapy does not require chemotherapy or immunosuppression thereby backing the redosability approach using engineered B cells.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Created using the Immune System Programming (ISP) platform of the company, ISP-001 has been granted orphan drug designation and rare paediatric disease designations from the FDA for MPS I.

Immusoft CEO Sean Ainsworth said: “This achievement marks an important milestone for patients with MPS I who have a significant need for additional therapeutic options. 

“This is the first patient in the world to receive an engineered B cell therapy – a major accomplishment for Immusoft and a major advancement in cell and gene therapy.”

MPS I impacts the ability of the body to create the enzyme alpha-L-iduronidase (IDUA), which is vital for disintegrating long-chain sugars inside cells. 

These sugars build up in the body without the IDUA enzyme, subsequently impacting eyes, heart, and bones among others.

Immusoft chief medical officer Robert Sikorski said: “I look forward to the next steps with this pioneering team of scientists and investigators as we advance the initial clinical trial in MPS I. 

“We are excited by the potential of expanding the Immusoft-engineered B cell platform to trials in additional therapeutic areas.”